Susanne Adams

TL;DR: It is shown with genetic experiments in mouse and zebrafish that ephrin-B2, a transmembrane ligand for Eph receptor tyrosine kinases, promotes sprouting behaviour and motility in the angiogenic endothelium, and shows that full VEGFR3 signalling is coupled to receptor internalization.

TL;DR: It is shown that the Notch ligand Jagged1 is a potent proangiogenic regulator in mice that antagonizes Dll4-Notch signaling in cells expressing Fringe family glycosyltransferases.

TL;DR: It is reported that mural cells require ephrin-B2, a ligand for Eph receptor tyrosine kinases, for normal association with small-diameter blood vessels (microvessels), and the results indicate that the role of e phrin- B2 and EphB receptors in these processes involves Crk-p130(CAS) signaling and suggest that ephin-B1 has some cell-cell-contact-independent functions.

TL;DR: This work shows that endocardial endothelial cells are progenitors of pericytes and vascular smooth muscle cells in the murine embryonic heart, identifying a novel and unexpected population of progenitor for coronary mural cells with potential relevance for heart function and disease conditions.

TL;DR: It is established that pericytes promote endothelial sprouting, which results in the loss of side branches and the enlargement of vessels when pericyte function is impaired or lost, thus regulating VEGF-induced endothelial cell sprouting in developing tissues.