Understanding the mechanisms and drivers of antimicrobial resistance
Alison Holmes,Luke S. P. Moore,Arnfinn Sundsfjord,Arnfinn Sundsfjord,Martin Steinbakk,Sadie Regmi,Abhilasha Karkey,Philippe J Guerin,Laura J. V. Piddock +8 more
TLDR
In this paper, the authors proposed a framework to combat the threat to human health and biosecurity from antimicrobial resistance, an understanding of its mechanisms and drivers is needed.About:
This article is published in The Lancet.The article was published on 2016-01-09 and is currently open access. It has received 1428 citations till now. The article focuses on the topics: Drug resistance & Antimicrobial.read more
Citations
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Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis
TL;DR: In this paper , the authors presented the most comprehensive estimates of AMR burden to date, which can be divided into five broad components: number of deaths where infection played a role, proportion of infectious deaths attributable to a given infectious syndrome, proportionof infectious syndrome deaths attributed to a particular pathogen, the percentage of a given pathogen resistant to an antibiotic of interest, and the excess risk of death or duration of an infection associated with this resistance.
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Antibiotic resistance: a rundown of a global crisis.
Bilal Aslam,Wei Wang,Muhammad Imran Arshad,Mohsin Khurshid,Saima Muzammil,Muhammad Hidayat Rasool,Muhammad Atif Nisar,Ruman Farooq Alvi,Muhammad Aamir Aslam,Muhammad Usman Qamar,Muhammad Khalid Farooq Salamat,Zulqarnain Baloch +11 more
TL;DR: Progressive alternate approaches including probiotics, antibodies, and vaccines have shown promising results in trials that suggest the role of these alternatives as preventive or adjunct therapies in future.
Journal ArticleDOI
Bacterial and Fungal Coinfection in Individuals With Coronavirus: A Rapid Review To Support COVID-19 Antimicrobial Prescribing.
Timothy M. Rawson,Timothy M. Rawson,Luke S. P. Moore,Luke S. P. Moore,Nina Zhu,Nishanthy Ranganathan,Nishanthy Ranganathan,Keira H. Skolimowska,Keira H. Skolimowska,Mark Gilchrist,Mark Gilchrist,Giovanni Satta,Giovanni Satta,Graham S Cooke,Graham S Cooke,Alison Holmes +15 more
TL;DR: Despite frequent prescription of broad-spectrum empirical antimicrobials in patients with coronavirus associated respiratory infections, there is a paucity of data to support the association with respiratory bacterial/fungal co-infection.
Journal ArticleDOI
Access to effective antimicrobials: a worldwide challenge.
Ramanan Laxminarayan,Ramanan Laxminarayan,Precious Matsoso,Suraj Pant,Charles H. Brower,John-Arne Røttingen,John-Arne Røttingen,Keith P. Klugman,Sally C Davies +8 more
TL;DR: The disease burden caused by limited access to antimicrobials, attributable to resistance to antimicrobial resistance, and the potential effect of vaccines in restricting the need for antibiotics are assessed.
Journal ArticleDOI
Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage
Rene S. Hendriksen,Patrick Munk,Patrick Murigu Kamau Njage,Bram A. D. van Bunnik,Luke McNally,Oksana Lukjancenko,Timo Röder,David F. Nieuwenhuijse,Susanne Karlsmose Pedersen,Jette Kjeldgaard,Rolf Sommer Kaas,Philip Thomas Lanken Conradsen Clausen,Josef Korbinian Vogt,Pimlapas Leekitcharoenphon,Milou G.M. van de Schans,T. Zuidema,Ana Maria de Roda Husman,Simon Rasmussen,Bent O. Petersen,Clara Amid,Guy Cochrane,Thomas Sicheritz-Pontén,Heike Schmitt,Jorge Raul Matheu Alvarez,Awa Aidara-Kane,Sünje Johanna Pamp,Ole Lund,Tine Hald,Mark E. J. Woolhouse,Marion Koopmans,Håkan Vigre,Thomas Nordahl Petersen,Frank Møller Aarestrup +32 more
TL;DR: It is suggested that global AMR gene diversity and abundance vary by region, and that improving sanitation and health could potentially limit the global burden of AMR.
References
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Antibiotic resistance—the need for global solutions
Ramanan Laxminarayan,Ramanan Laxminarayan,Ramanan Laxminarayan,Adriano Duse,Chand Wattal,Anita K. M. Zaidi,Heiman F. L. Wertheim,Nithima Sumpradit,Erika Vlieghe,Gabriel Levy Hara,Ian M. Gould,Herman Goossens,Christina Greko,Anthony D. So,Maryam Bigdeli,Goeran Tomson,Will Woodhouse,Eva Ombaka,Arturo Quizhpe Peralta,Farah Naz Qamar,Fatima Mir,Sam Kariuki,Zulfigar A. Bhutta,Anthony R.M. Coates,Richard Bergstrom,Gerard D. Wright,Eric D. Brown,Otto Cars +27 more
TL;DR: The global situation of antibiotic resistance, its major causes and consequences, and key areas in which action is urgently needed are described and identified.
Journal ArticleDOI
Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile
Els van Nood,A. Vrieze,Max Nieuwdorp,Susana Fuentes,Erwin G. Zoetendal,Willem M. de Vos,Caroline E. Visser,Ed J. Kuijper,Peter Speelman,Josbert J. Keller +9 more
TL;DR: The infusion of donor feces was significantly more effective for the treatment of recurrent C. difficile infection than the use of vancomycin and patients showed increased fecal bacterial diversity, similar to that in healthy donors, with an increase in Bacteroidetes species and clostridium clusters IV and XIVa and a decrease in Proteobacteria species.
Journal ArticleDOI
Outpatient antibiotic use in Europe and association with resistance: a cross-national database study
TL;DR: Outpatient antibiotic use in 26 countries in Europe between Jan 1, 1997, and Dec 31, 2002 was investigated by calculating the number of defined daily doses (DDD) per 1000 inhabitants per day according to WHO anatomic therapeutic chemical classification and DDD measurement methodology, and the ecological association between antibiotic use and antibiotic resistance rates was assessed using Spearman's correlation coefficients.
Journal ArticleDOI
A new antibiotic kills pathogens without detectable resistance
Losee Lucy Ling,Tanja Schneider,Aaron J. Peoples,Amy Spoering,Ina Engels,Brian P. Conlon,A. Mueller,Till F. Schäberle,Dallas Hughes,Slava S. Epstein,M. Jones,Linos Lazarides,Victoria Alexandra Steadman,Cohen Dr,Cintia R. Felix,Fetterman Ka,William Millett,Anthony Nitti,Ashley Zullo,Chao Chen,Kim Lewis +20 more
TL;DR: The properties of this compound suggest a path towards developing antibiotics that are likely to avoid development of resistance, as well as several methods to grow uncultured organisms by cultivation in situ or by using specific growth factors.
Journal ArticleDOI
Heavy use of prophylactic antibiotics in aquaculture: a growing problem for human and animal health and for the environment
TL;DR: Global efforts are needed to promote more judicious use of prophylactic antibiotics in aquaculture as accumulating evidence indicates that unrestricted use is detrimental to fish, terrestrial animals, and human health and the environment.
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