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Yon Ko

Researcher at University of Bonn

Publications -  155
Citations -  8881

Yon Ko is an academic researcher from University of Bonn. The author has contributed to research in topics: Breast cancer & Vascular smooth muscle. The author has an hindex of 48, co-authored 143 publications receiving 8346 citations. Previous affiliations of Yon Ko include Medical University of Vienna & University of Tübingen.

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Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size.

TL;DR: It is demonstrated that OPN modifies primitive hematopoietic cell number and function in a stem cell–nonautonomous manner and may provide a mechanism for restricting excess stem cell expansion under conditions of niche stimulation.
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Associations of Breast Cancer Risk Factors With Tumor Subtypes: A Pooled Analysis From the Breast Cancer Association Consortium Studies

Xiaohong R. Yang, +173 more
TL;DR: It is shown that reproductive factors and BMI are most clearly associated with hormone receptor-positive tumors and suggest that triple-negative or CBP tumors may have distinct etiology.
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Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

Stig E. Bojesen, +455 more
- 01 Apr 2013 - 
TL;DR: Using the Illumina custom genotyping array iCOGs, SNPs at the TERT locus in breast, ovarian and BRCA1 mutation carrier cancer cases and controls and leukocyte telomere measurements are analyzed to find associations cluster into three independent peaks.
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Prediction of Breast Cancer Risk Based on Profiling With Common Genetic Variants

Nasim Mavaddat, +242 more
TL;DR: The PRS stratifies breast cancer risk in women both with and without a family history of breast cancer, and the observed level of risk discrimination could inform targeted screening and prevention strategies.
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Genome-wide association studies identify four ER negative-specific breast cancer risk loci

Montserrat Garcia-Closas, +287 more
- 01 Apr 2013 - 
TL;DR: SNPs at four loci were associated with ER-negative but not ER-positive breast cancer (P > 0.05), providing further evidence for distinct etiological pathways associated with invasive ER- positive and ER- negative breast cancers.