L
Laura M. Raffield
Researcher at University of North Carolina at Chapel Hill
Publications - 179
Citations - 4816
Laura M. Raffield is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Genome-wide association study & Medicine. The author has an hindex of 23, co-authored 124 publications receiving 1948 citations. Previous affiliations of Laura M. Raffield include Medical University of South Carolina & Wake Forest University.
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Abstract 3507: Mosaic chromosomal alterations in blood across ancestries via whole-genome sequencing
Yasminka A. Jakubek,Ying Zhou,Adrienne M. Stilp,Jason Bacon,Justin Wong,Zuhal Ozcan,Donna K. Arnett,Kathleen C. Barnes,Joshua A Bis,Eric Boerwinkle,April P Carson,Daniel I. Chasman,Mi Ae Cho,Matthew P. Conomos,Nancy J. Cox,Margaret F. Doyle,Myriam Fornage,Xiuqing Guo,Sharon L.R. Kardia,Joshua P. Lewis,Ruth J. F. Loos,X. Ma,Mitchell J. Machiela,T. Mack,Rasika A. Mathias,Braxton D. Mitchell,Kari E. North,Nathan Pankratz,Patricia A. Peyser,Michael Preuss,Bruce M. Psaty,Laura M. Raffield,Ramachandran S. Vasan,Susan Redline,Stephen S. Rich,Jerome I. Rotter,Edwin K. Silverman,Jennifer A. Smith,Margaret A. Taub,Jeong H. Yun,Yun Li,Pinkal Desai,Alexander G. Bick,Alexander P. Reiner,Paul Scheet,Paul L. Auer +45 more
TL;DR: Jakubek et al. as mentioned in this paper found that individuals of European ancestry have the highest rates of chromosome X mCAs, mirroring the higher rate of leukemia in this group.
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Criteria for level 1 and level 2 trauma codes: Are pelvic ring injuries undertriaged?
TL;DR: Trauma code level assignment is not correlated with severity of pelvic injury, and because an unstable pelvis can lead to hemodynamic instability, these injuries may be undertriaged.
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Abstract P248: Plasma Proteins Associated With Depressive Symptoms and Perceived Global Stress Among African American Adults in the Jackson Heart Study
Sara O'Brien,Brian Chen,Daniel E. Cruz,Alexander P. Reiner,Mario Sims,LáShauntá M. Glover,Laura M. Raffield +6 more
TL;DR: In this paper , the authors used multivariable linear models to test the association between depressive symptoms and global stress scores and proteins, controlling for age, sex, and proteomics batch.
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Abstract P197: HbA1c Partially Mediates the Effect of Tyrosine and Phenylalanine on Incident Myocardial Infarction
Sarah H Koenigsberg,Mariaelisa Graff,Anna F Ballou,Carolina Downie,Annie Green Howard,Moa P. Lee,Kari E. North,Laura M. Raffield,Rina Yarosh,Penny Gordon-Larsen,Christy L. Avery +10 more
TL;DR: In this paper , the authors evaluated associations between two aromatic amino acids - tyrosine and phenylalanine - with a broad range of phenotypic categories in the UK Biobank using polygenic risk score (PRS) instrumental variables and tested for mediation by glycated hemoglobin (HbA1c) as a measure of insulin resistance.
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Canonical correlation analysis for multi-omics: Application to cross-cohort analysis
Min-Zhi Jiang,François Aguet,Kristin G. Ardlie,Jiawen Chen,Elaine Cornell,Daniel E. Cruz,Peter Durda,Stacey Gabriel,Robert E. Gerszten,Xiuqing Guo,Craig Johnson,Silva Kasela,Leslie A. Lange,Tuuli Lappalainen,Yongmei Liu,Alexander P. Reiner,Josh Smith,Tamar Sofer,Kent D. Taylor,Russell P. Tracy,David J. Vandenberg,James F. Wilson,Stephen S. Rich,Jerome I. Rotter,Michael I. Love,Laura M. Raffield,Yun Li +26 more
TL;DR: In this article , the authors adapted sparse multiple CCA (SMCCA) to proteomics and methylomics data from the Multi-Ethnic Study of Atherosclerosis (MESA) and Jackson Heart Study (JHS).