L
Laura M. Raffield
Researcher at University of North Carolina at Chapel Hill
Publications - 179
Citations - 4816
Laura M. Raffield is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Genome-wide association study & Medicine. The author has an hindex of 23, co-authored 124 publications receiving 1948 citations. Previous affiliations of Laura M. Raffield include Medical University of South Carolina & Wake Forest University.
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Journal ArticleDOI
Importance of Genetic Studies of Cardiometabolic Disease in Diverse Populations
Lindsay Fernández-Rhodes,Kristin L. Young,Adam G. Lilly,Laura M. Raffield,Heather M. Highland,Genevieve L. Wojcik,Cary S. Agler,Shelly Ann Love,Samson Okello,Samson Okello,Samson Okello,Lauren E. Petty,Lauren E. Petty,Mariaelisa Graff,Jennifer E. Below,Jennifer E. Below,Kimon Divaris,Kari E. North +17 more
TL;DR: The imperativeness of studying the populations who are most affected by cardiometabolic disease is described, and additional, unprecedented opportunities lie ahead for public health genomics and the realization of precision medicine, provided that the gap in diversity can be systematically addressed.
Journal ArticleDOI
Predictors of all-cause and cardiovascular disease mortality in type 2 diabetes: Diabetes Heart Study
Laura M. Raffield,Fang-Chi Hsu,Amanda J. Cox,J. Jeffrey Carr,Barry I. Freedman,Donald W. Bowden +5 more
TL;DR: This analysis highlights important demographic and clinical factors, notably CAC and albuminuria, which predict mortality in the general population of patients with type 2 diabetes, as well as Cox proportional hazards models with sandwich-based variance estimation.
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Genetic discovery and risk characterization in type 2 diabetes across diverse populations
Linda M. Polfus,Burcu F. Darst,Heather M. Highland,Xin Sheng,Maggie C.Y. Ng,Jennifer E. Below,Lauren E. Petty,Stephanie A. Bien,Xueling Sim,Wei Wang,Pierre Fontanillas,Yesha Patel,Michael Preuss,Claudia Schurmann,Zhaohui Du,Yingchang Lu,Suhn K. Rhie,Joseph M. Mercader,Teresa Tusié-Luna,Clicerio González-Villalpando,Lorena Orozco,Cassandra N. Spracklen,Brian E. Cade,Richard A. Jensen,Meng Sun,Yoonjung Yoonie Joo,Ping An,Lisa R. Yanek,Lawrence F. Bielak,Salman M. Tajuddin,Aude Nicolas,Guanjie Chen,Laura M. Raffield,Xiuqing Guo,Wei-Min Chen,Girish N. Nadkarni,Mariaelisa Graff,Ran Tao,James S. Pankow,Martha L. Daviglus,Qibin Qi,Eric Boerwinkle,Simin Liu,Lawrence S. Phillips,Lawrence S. Phillips,Ulrike Peters,Christopher S. Carlson,Lynne R. Wikens,Loic Le Marchand,Kari E. North,Steven Buyske,Charles Kooperberg,Ruth J. F. Loos,Daniel O. Stram,Christopher A. Haiman +54 more
TL;DR: A multiethnic genome-wide association study of T2D among 53,102 cases and 193,679 control subjects from African, Hispanic, Asian, Native Hawaiian, and European population groups shows the urgent need to further increase representation of non-European ancestry individuals in genetics research to improve genetic-based risk prediction across populations.
Journal ArticleDOI
Associations between anxiety and depression symptoms and cognitive testing and neuroimaging in type 2 diabetes
Laura M. Raffield,Gretchen A. Brenes,Amanda J. Cox,Barry I. Freedman,Christina E. Hugenschmidt,Fang-Chi Hsu,Jianzhao Xu,Benjamin C. Wagner,Jeff D. Williamson,Joseph A. Maldjian,Donald W. Bowden +10 more
TL;DR: Comorbid anxiety and depression symptoms were associated with cognitive performance and brain structure in a European American cohort with type 2 diabetes, and were somewhat attenuated upon further adjustment for health status related covariates.
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Association of mitochondrial DNA copy number with cardiometabolic diseases
Xue Liu,Ryan J. Longchamps,Kerri L. Wiggins,Laura M. Raffield,Lawrence F. Bielak,Wei Zhao,Achilleas N. Pitsillides,Thomas W. Blackwell,Jie Yao,Xiuqing Guo,Nuzulul Kurniansyah,Bharat Thyagarajan,Nathan Pankratz,Stephen S. Rich,Kent D. Taylor,Patricia A. Peyser,Susan R. Heckbert,Sudha Seshadri,Sudha Seshadri,Sudha Seshadri,L. Adrienne Cupples,Eric Boerwinkle,Eric Boerwinkle,Megan L. Grove,Nicholas B. Larson,Jennifer A. Smith,Ramachandran S. Vasan,Ramachandran S. Vasan,Tamar Sofer,Tamar Sofer,Annette L. Fitzpatrick,Myriam Fornage,Jun Ding,Adolfo Correa,Gonçalo R. Abecasis,Bruce M. Psaty,James G. Wilson,Daniel Levy,Jerome I. Rotter,Joshua C. Bis,Claudia L. Satizabal,Claudia L. Satizabal,Claudia L. Satizabal,Dan E. Arking,Chunyu Liu,Chunyu Liu +45 more
TL;DR: The observed decline in mtDNA CN after 65 years of age may be a key to understanding age-related diseases.