L
Laura M. Raffield
Researcher at University of North Carolina at Chapel Hill
Publications - 179
Citations - 4816
Laura M. Raffield is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Genome-wide association study & Medicine. The author has an hindex of 23, co-authored 124 publications receiving 1948 citations. Previous affiliations of Laura M. Raffield include Medical University of South Carolina & Wake Forest University.
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Journal ArticleDOI
Structural and functional assessment of the brain in European Americans with mild-to-moderate kidney disease: Diabetes Heart Study-MIND
Mariana Murea,Fang-Chi Hsu,Amanda J. Cox,Christina E. Hugenschmidt,Jianzhao Xu,Jeremy N. Adams,Laura M. Raffield,Christopher T. Whitlow,Joseph A. Maldjian,Donald W. Bowden,Barry I. Freedman +10 more
TL;DR: In EAs with mild CKD enriched for T2D, brain structure and cognitive performance were generally not impacted and longitudinal studies are necessary to determine when cerebral structural changes and cognitive dysfunction develop with progressive CKD in EAs.
Journal ArticleDOI
Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed
Margaret A. Taub,Matthew P. Conomos,Rebecca Keener,Kruthika R. Iyer,Joshua S. Weinstock,Lisa R. Yanek,John Lane,Tyne W. Miller-Fleming,Jennifer A. Brody,Laura M. Raffield,Caitlin P. McHugh,Deepti Jain,Stephanie M. Gogarten,Cecelia A. Laurie,Ali R. Keramati,Marios Arvanitis,Benjamin D. Heavner,Lucas Barwick,Lewis C. Becker,Joshua C. Bis,John Blangero,Eugene R. Bleecker,Esteban G. Burchard,Juan C. Celedón,Yen Pei C. Chang,Brian Custer,Dawood Darbar,L. de las Fuentes,Dawn L. DeMeo,Barry I. Freedman,Melanie E. Garrett,Mark T. Gladwin,Susan R. Heckbert,Bertha Hidalgo,Marguerite R. Irvin,Talat Islam,W. Craig Johnson,Stefan Kaab,Lenore J. Launer,Jiwon Lee,Simin Liu,Arden Moscati,Kari E. North,Patricia A. Peyser,Nicholas Rafaels,Christine E. Seidman,Daniel E. Weeks,Fayun Wen,Marsha M. Wheeler,L. Keoki Williams,Ivana V. Yang,Wei Zhao,Stella Aslibekyan,Paul L. Auer,Donald W. Bowden,Brian E. Cade,Zhanghua Chen,Michael Chopp,L. Adrienne Cupples,Joanne E. Curran,Michelle Daya,Ranjan Deka,Celeste Eng,Tasha E. Fingerlin,Xiuqing Guo,Lifang Hou,Shih-Jen Hwang,Jill M. Johnsen,Eimear E. Kenny,Albert M. Levin,Chunyu Liu,Ryan L. Minster,Take Naseri,Mehdi Nouraie,Muagututi‘a Sefuiva Reupena,Ester Cerdeira Sabino,Jennifer A. Smith,Nicholas L. Smith,Jessica Lasky-Su,James G. Taylor,Marilyn J. Telen,Hemant K. Tiwari,Russell P. Tracy,Marquitta J. White,Yingze Zhang,Kerri L. Wiggins,Scott T. Weiss,Ramachandran S. Vasan,Kent D. Taylor,Moritz F. Sinner,Edwin K. Silverman,M. Benjamin Shoemaker,Wayne H-H Sheu,Frank C. Sciurba,David A. Schwartz,Jerome I. Rotter,Dan Roden,Susan Redline,Benjamin A. Raby,Bruce M. Psaty,Juan M. Peralta,Nicholette D. Palmer,Sergei Nekhai,Courtney G. Montgomery,Braxton D. Mitchell,Deborah A. Meyers,Stephen T. McGarvey,Angel C.Y. Mak,Ruth J. F. Loos,Rajesh P C Kumar,Charles Kooperberg,Barbara A. Konkle,Shannon Jeanne Kelly,Sharon L.R. Kardia,Robert Kaplan,Jiang He,Hongsheng Gui,Frank D. Gilliland,Bruce D. Gelb,Myriam Fornage,Patrick T. Ellinor,Mariza de Andrade,Adolfo Correa,Yii-Der Ida Chen,Eric Boerwinkle,Kathleen C. Barnes,Allison E. Ashley-Koch,Donna K. Arnett,Christine A Albert,Cathy C. Laurie,Gonçalo R. Abecasis,Deborah A. Nickerson,James F. Wilson,Stephen S. Rich,Daniel Levy,Ingo Ruczinski,Abraham Aviv,Thomas W. Blackwell,Timothy A. Thornton,Jeffrey R. O'Connell,Nancy J. Cox,James A. Perry,Mary Armanios,Alexis Battle,Nathan Pankratz,Alexander P. Reiner,Rasika A. Mathias +146 more
TL;DR: This article reported the first sequencing-based association study for TL across ancestrally-diverse individuals (European, African, Asian and Hispanic/Latino) from the NHLBI Trans-Omics for Precision Medicine (TOPMed) program.
Posted ContentDOI
Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole Genomes
Alexander G. Bick,Joshua S. Weinstock,Satish K. Nandakumar,Charles P. Fulco,Matthew Leventhal,Erik L. Bao,Joseph Nasser,Seyedeh M. Zekavat,Mindy D. Szeto,Cecelia A. Laurie,Margaret A. Taub,Braxton D. Mitchell,Kathleen C. Barnes,Arden Moscati,Myriam Fornage,Susan Redline,Bruce M. Psaty,Edwin K. Silverman,Scott T. Weiss,Nicholette D. Palmer,Ramachandran S. Vasan,Esteban G. Burchard,Sharon L.R. Kardia,Jiang He,Robert C. Kaplan,Nicholas L. Smith,Donna K. Arnett,David A. Schwartz,Adolfo Correa,Mariza de Andrade,Xiuqing Guo,Barbara A. Konkle,Brian Custer,Juan M. Peralta,Hongsheng Gui,Deborah A. Meyers,Stephen T. McGarvey,Ida Yii-Der Chen,M. Benjamin Shoemaker,Patricia A Peyser,Jai G. Broome,Stephanie M. Gogarten,Fei Fei Wang,Quenna Wong,May E Montasser,Michelle Daya,Eimear E. Kenny,Kari E. North,Lenore J. Launer,Brian E. Cade,Joshua C. Bis,Michael H. Cho,Jessica Lasky-Su,Donald W. Bowden,L. Adrienne Cupples,A.C.Y. Mak,Lewis C. Becker,Jennifer A. Smith,Tanika N. Kelly,Stella Aslibekyan,Susan R. Heckbert,Hemant K. Tiwari,Ivana V. Yang,John A. Heit,Steven A. Lubitz,Stephen S. Rich,Jill M. Johnsen,Joanne E. Curran,Sally E. Wenzel,Daniel E. Weeks,Dabeeru C. Rao,Dawood Darbar,Jee-Young Moon,Russell P. Tracy,Erin J Buth,Nicholas Rafaels,Ruth J. F. Loos,Lifang Hou,Jiwon Lee,Priyadarshini Kachroo,Barry I. Freedman,Daniel Levy,Lawrence F. Bielak,James E. Hixson,James S. Floyd,Eric A. Whitsel,Patrick T. Ellinor,Marguerite R. Irvin,Tasha E. Fingerlin,Laura M. Raffield,Sebastian M. Armasu,Jerome I. Rotter,Marsha M. Wheeler,Ester Cerdeira Sabino,John Blangero,L. Keoki Williams,Bruce D. Levy,Wayne Huey-Herng Sheu,Dan M. Roden,Eric Boerwinkle,JoAnn E. Manson,Rasika A. Mathias,Pinkal Desai,Kent D. Taylor,Andrew D. Johnson,Paul L. Auer,Charles Kooperberg,Cathy C. Laurie,Thomas W. Blackwell,Albert V. Smith,Hongyu Zhao,Ethan M. Lange,Leslie A. Lange,James G. Wilson,Eric S. Lander,Jesse M. Engreitz,Benjamin L. Ebert,Alexander P. Reiner,Vijay G. Sankaran,Sidd Jaiswal,Gonçalo R. Abecasis,Pradeep Natarajan,Sekar Kathiresan +122 more
TL;DR: Overall, it is observed that germline genetic variation altering hematopoietic stem cell function and the fidelity of DNA-damage repair increase the likelihood of somatic mutations leading to CHIP.
Journal ArticleDOI
Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program.
Yao Hu,Adrienne M. Stilp,Caitlin P. McHugh,Shuquan Rao,Deepti Jain,Xiuwen Zheng,John Lane,Sébastian Méric de Bellefon,Laura M. Raffield,Ming-Huei Chen,Lisa R. Yanek,Marsha M. Wheeler,Yao Yao,Chunyan Ren,Jai G. Broome,Jee-Young Moon,Paul S. de Vries,Brian D. Hobbs,Quan Sun,Praveen Surendran,Jennifer A. Brody,Thomas W. Blackwell,Hélène Choquet,Kathleen A. Ryan,Ravindranath Duggirala,Nancy L. Heard-Costa,Nancy L. Heard-Costa,Zhe Wang,Nathalie Chami,Michael Preuss,Nancy Min,Lynette Ekunwe,Leslie A. Lange,Mary Cushman,Nauder Faraday,Joanne E. Curran,Laura Almasy,Kousik Kundu,Kousik Kundu,Albert V. Smith,Stacey Gabriel,Jerome I. Rotter,Myriam Fornage,Donald M. Lloyd-Jones,Ramachandran S. Vasan,Nicholas L. Smith,Nicholas L. Smith,Nicholas L. Smith,Kari E. North,Eric Boerwinkle,Lewis C. Becker,Joshua P. Lewis,Gonçalo R. Abecasis,Lifang Hou,Jeffrey R. O'Connell,Alanna C. Morrison,Terri H. Beaty,Robert C. Kaplan,Adolfo Correa,John Blangero,Eric Jorgenson,Bruce M. Psaty,Bruce M. Psaty,Charles Kooperberg,Russell T. Walton,Benjamin P. Kleinstiver,Hua Tang,Ruth J. F. Loos,Nicole Soranzo,Adam S. Butterworth,Deborah A. Nickerson,Stephen S. Rich,Braxton D. Mitchell,Andrew D. Johnson,Paul L. Auer,Yun Li,Rasika A. Mathias,Guillaume Lettre,Guillaume Lettre,Nathan Pankratz,Cathy C. Laurie,Cecelia A. Laurie,Daniel E. Bauer,Matthew P. Conomos,Alexander P. Reiner +84 more
TL;DR: In this paper, the authors leveraged whole-genome sequencing (WGS) data in up to 62,653 ethnically diverse participants from the NHLBI Trans-Omics for Precision Medicine (TOPMed) program and assessed statistical association of variants with seven red blood cell (RBC) quantitative traits.
Journal ArticleDOI
Genome-wide association study of heart rate and its variability in Hispanic/Latino cohorts.
Kathleen F. Kerr,Christy L. Avery,Henry J. Lin,Laura M. Raffield,Qian S. Zhang,Brian L. Browning,Sharon R. Browning,Matthew P. Conomos,Stephanie M. Gogarten,Cathy C. Laurie,Tamar Sofer,Timothy A. Thornton,Chancellor Hohensee,Rebecca D. Jackson,Charles Kooperberg,Yun Li,Raul Mendez-Giraldez,Marco V Perez,Ulrike Peters,Alexander P. Reiner,Zhu Ming Zhang,Jie Yao,Nona Sotoodehnia,Kent D. Taylor,Xiuqing Guo,Leslie A. Lange,Elsayed Z. Soliman,James G. Wilson,Jerome I. Rotter,Susan R. Heckbert,Deepti Jain,Eric A. Whitsel +31 more
TL;DR: This first genome-wide association study of HRV and HR in Hispanics/Latinos underscores the potential for even modestly sized samples of non-European ancestry to inform the genetic epidemiology of complex traits.