M
Margaret A. Taub
Researcher at Johns Hopkins University
Publications - 86
Citations - 3890
Margaret A. Taub is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Genome-wide association study & Gene. The author has an hindex of 23, co-authored 71 publications receiving 2842 citations. Previous affiliations of Margaret A. Taub include University of California, San Francisco & University of California.
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Journal ArticleDOI
Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis
Yun Liu,Martin J. Aryee,Leonid Padyukov,M. Daniele Fallin,M. Daniele Fallin,Espen Hesselberg,Arni Runarsson,Lovisa E. Reinius,Nathalie Acevedo,Margaret A. Taub,Margaret A. Taub,Marcus Ronninger,Klementy Shchetynsky,Annika Scheynius,Juha Kere,Lars Alfredsson,Lars Klareskog,Tomas J. Ekström,Andrew P. Feinberg,Andrew P. Feinberg +19 more
TL;DR: DNA methylation is a potential mediator of genetic risk for rheumatoid arthritis and is corrected for cellular heterogeneity by estimating and adjusting for cell-type proportions in blood-derived DNA samples and used mediation analysis to filter out associations likely to be a consequence of disease.
Journal ArticleDOI
Reproducible RNA-seq analysis using recount2.
Leonardo Collado-Torres,Abhinav Nellore,Kai Kammers,Kai Kammers,Shannon E. Ellis,Margaret A. Taub,Kasper D. Hansen,Andrew E. Jaffe,Ben Langmead,Jeffrey T. Leek +9 more
TL;DR: This work presents a new generation of probabilistic models that combine RNAseq, a very simple and scalable approach to genome annotation, with real-time information about the “wear and tear” of the genome.
Journal ArticleDOI
Inherited causes of clonal haematopoiesis in 97,691 whole genomes.
Alexander G. Bick,Joshua S. Weinstock,Satish K. Nandakumar,Satish K. Nandakumar,Charles P. Fulco,Charles P. Fulco,Erik L. Bao,Erik L. Bao,Seyedeh M. Zekavat,Seyedeh M. Zekavat,Mindy D. Szeto,Xiaotian Liao,Xiaotian Liao,Matthew Leventhal,Joseph Nasser,Kyle Chang,Cecelia A. Laurie,Bala Bharathi Burugula,Christopher J. Gibson,Amy E. Lin,Margaret A. Taub,François Aguet,Kristin G. Ardlie,Braxton D. Mitchell,Braxton D. Mitchell,Kathleen C. Barnes,Kathleen C. Barnes,Arden Moscati,Myriam Fornage,Susan Redline,Susan Redline,Susan Redline,Bruce M. Psaty,Edwin K. Silverman,Edwin K. Silverman,Scott T. Weiss,Scott T. Weiss,Nicholette D. Palmer,Ramachandran S. Vasan,Esteban G. Burchard,Sharon L.R. Kardia,Jiang He,Robert C. Kaplan,Robert C. Kaplan,Nicholas L. Smith,Nicholas L. Smith,Nicholas L. Smith,Donna K. Arnett,David A. Schwartz,Adolfo Correa,Mariza de Andrade,Xiuqing Guo,Barbara A. Konkle,Brian Custer,Juan M. Peralta,Hongsheng Gui,Deborah A. Meyers,Stephen T. McGarvey,Ida Yii-Der Chen,M. Benjamin Shoemaker,Patricia A. Peyser,Jai G. Broome,Stephanie M. Gogarten,Fei Fei Wang,Quenna Wong,May E. Montasser,Michelle Daya,Eimear E. Kenny,Kari E. North,Lenore J. Launer,Brian E. Cade,Brian E. Cade,Joshua C. Bis,Michael H. Cho,Michael H. Cho,Jessica Lasky-Su,Jessica Lasky-Su,Donald W. Bowden,L. Adrienne Cupples,Angel C.Y. Mak,Lewis C. Becker,Jennifer A. Smith,Tanika N. Kelly,Stella Aslibekyan,Susan R. Heckbert,Susan R. Heckbert,Hemant K. Tiwari,Ivana V. Yang,John A. Heit,Steven A. Lubitz,Steven A. Lubitz,Jill M. Johnsen,Joanne E. Curran,Sally E. Wenzel,Daniel E. Weeks,Dabeeru C. Rao,Dawood Darbar,Jee-Young Moon,Russell P. Tracy,Erin J Buth,Nicholas Rafaels,Ruth J. F. Loos,Peter Durda,Yongmei Liu,Lifang Hou,Jiwon Lee,Priyadarshini Kachroo,Priyadarshini Kachroo,Barry I. Freedman,Daniel Levy,Lawrence F. Bielak,James E. Hixson,James S. Floyd,Eric A. Whitsel,Patrick T. Ellinor,Patrick T. Ellinor,Marguerite R. Irvin,Tasha E. Fingerlin,Laura M. Raffield,Sebastian M. Armasu,Marsha M. Wheeler,Ester Cerdeira Sabino,John Blangero,L. Keoki Williams,Bruce D. Levy,Bruce D. Levy,Wayne Huey-Herng Sheu,Dan M. Roden,Eric Boerwinkle,Eric Boerwinkle,JoAnn E. Manson,JoAnn E. Manson,Rasika A. Mathias,Pinkal Desai,Kent D. Taylor,Andrew D. Johnson,Paul L. Auer,Charles Kooperberg,Cathy C. Laurie,Thomas W. Blackwell,Albert V. Smith,Hongyu Zhao,Ethan M. Lange,Leslie A. Lange,Stephen S. Rich,Jerome I. Rotter,James G. Wilson,James G. Wilson,Paul Scheet,Jacob O. Kitzman,Eric S. Lander,Eric S. Lander,Eric S. Lander,Jesse M. Engreitz,Jesse M. Engreitz,Benjamin L. Ebert,Alexander P. Reiner,Alexander P. Reiner,Siddhartha Jaiswal,Gonçalo R. Abecasis,Gonçalo R. Abecasis,Vijay G. Sankaran,Vijay G. Sankaran,Sekar Kathiresan,Pradeep Natarajan,Pradeep Natarajan +165 more
TL;DR: Analysis of high-coverage whole-genome sequences from 97,691 participants of diverse ancestries in the National Heart, Lung, and Blood Institute Trans-omics for Precision Medicine programme enables simultaneous identification of germline and somatic mutations that predispose individuals to clonal expansion of haematopoietic stem cells.
Journal ArticleDOI
Assembly of a pan-genome from deep sequencing of 910 humans of African descent
Rachel M. Sherman,Juliet Forman,Juliet Forman,Valentin Antonescu,Daniela Puiu,Michelle Daya,Nicholas Rafaels,Meher Preethi Boorgula,Sameer Chavan,Candelaria Vergara,Victor E. Ortega,Albert M. Levin,Celeste Eng,Maria Yazdanbakhsh,James G. Wilson,Javier Marrugo,Leslie A. Lange,L. Keoki Williams,Harold Watson,Lorraine B. Ware,Christopher O. Olopade,Olufunmilayo I. Olopade,Ricardo Riccio Oliveira,Carole Ober,Dan L. Nicolae,Deborah A. Meyers,Alvaro Mayorga,Jennifer Knight-Madden,Tina V. Hartert,Nadia N. Hansel,Marilyn G. Foreman,Jean G. Ford,Mezbah U. Faruque,Georgia M. Dunston,Luis Caraballo,Esteban G. Burchard,Eugene R. Bleecker,Maria Ilma Araujo,Edwin Francisco Herrera-Paz,Monica Campbell,Cassandra Foster,Margaret A. Taub,Terri H. Beaty,Ingo Ruczinski,Rasika A. Mathias,Kathleen C. Barnes,Steven L. Salzberg +46 more
TL;DR: A deeply sequenced dataset of 910 individuals, all of African descent, is used to construct a set of DNA sequences that is present in these individuals but missing from the reference human genome, demonstrating that the African pan-genome contains ~10% more DNA than the current human reference genome.
Journal ArticleDOI
Identification of Functional Variants for Cleft Lip with or without Cleft Palate in or near PAX7, FGFR2, and NOG by Targeted Sequencing of GWAS Loci
Elizabeth J. Leslie,Margaret A. Taub,Huan Liu,Huan Liu,Karyn Meltz Steinberg,Daniel C. Koboldt,Qunyuan Zhang,Jenna C. Carlson,Jacqueline B. Hetmanski,Hang Wang,David E. Larson,Robert S. Fulton,Youssef A. Kousa,Walid D. Fakhouri,Ali Naji,Ingo Ruczinski,Ferdouse Begum,Margaret M. Parker,Tamara Busch,Jennifer Standley,Jennifer Rigdon,Jacqueline T. Hecht,Alan F. Scott,George L. Wehby,Kaare Christensen,Andrew E. Czeizel,Frederic W.-B. Deleyiannis,Brian C. Schutte,Richard K. Wilson,Robert A. Cornell,Andrew C. Lidral,George M. Weinstock,Terri H. Beaty,Mary L. Marazita,Jeffrey C. Murray +34 more
TL;DR: This targeted sequencing study provides strong functional evidence implicating several specific variants as primary contributory risk alleles for nonsyndromic clefting in humans.