Roland Nilsson

TL;DR: Detailed polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development.

TL;DR: Glycine consumption and expression of the mitochondrial glycine biosynthetic pathway was identified as strongly correlated with rates of proliferation across cancer cells, and higher expression of this pathway was associated with greater mortality in breast cancer patients.

TL;DR: This study compares messenger RNA profiles of 1,454 metabolic enzymes across 1,981 tumours spanning 19 cancer types to identify enzymes that are consistently differentially expressed and highlights the importance of mitochondrial compartmentalization of one-carbon metabolism in cancer and raises important therapeutic hypotheses.

TL;DR: The antiemetic meclizine pretreatment confers cardioprotection and neuroprotection against ischemia-reperfusion injury in murine models andNutrient-sensitized screening may provide a useful framework for understanding gene function and drug action within the context of energy metabolism.

TL;DR: Septin filaments and phosphatidylinositol-4,5-bisphosphate rearrange locally at endoplasmic reticulum–plasma membrane junctions before and during formation ofSTIM1–ORAI1 clusters, facilitating STIM1 targeting to these junctions and promoting the stable recruitment of ORAI1.