L
Lauren I.R. Ehrlich
Researcher at University of Texas at Austin
Publications - 48
Citations - 6858
Lauren I.R. Ehrlich is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: T cell & Central tolerance. The author has an hindex of 22, co-authored 41 publications receiving 6270 citations. Previous affiliations of Lauren I.R. Ehrlich include University of California, San Francisco & Stanford University.
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Journal ArticleDOI
Epigenetic memory in induced pluripotent stem cells
Kibem Kim,Akiko Doi,Bo Wen,K. Ng,Rui Zhao,Patrick Cahan,Jonghwan Kim,Martin J. Aryee,Hong Ji,Lauren I.R. Ehrlich,Lauren I.R. Ehrlich,A. Yabuuchi,A. Takeuchi,K. C. Cunniff,H. Hongguang,Shannon McKinney-Freeman,Olaia Naveiras,T. J. Yoon,T. J. Yoon,Rafael A. Irizarry,Namyoung Jung,Jun Seita,Jacob H. Hanna,Peter Murakami,Rudolf Jaenisch,Ralph Weissleder,Stuart H. Orkin,Irving L. Weissman,Andrew P. Feinberg,George Q. Daley +29 more
TL;DR: It is observed that low-passage induced pluripotent stem cells (iPSCs) derived by factor-based reprogramming of adult murine tissues harbour residual DNA methylation signatures characteristic of their somatic tissue of origin, which favours their differentiation along lineages related to the donor cell, while restricting alternative cell fates.
Epigenetic memory in induced pluripotent stem cells
Kibem Kim,Akiko Doi,Bo Wen,K. Ng,Rui Zhao,Patrick Cahan,Jonghwan Kim,Martin J. Aryee,Hong Ji,Lauren I.R. Ehrlich,Lauren I.R. Ehrlich,A. Yabuuchi,A. Takeuchi,K. C. Cunniff,H. Hongguang,Shannon McKinney-Freeman,Olaia Naveiras,T. J. Yoon,T. J. Yoon,Rafael A. Irizarry,Namyoung Jung,Jun Seita,Jacob H. Hanna,Peter Murakami,Rudolf Jaenisch,Ralph Weissleder,Stuart H. Orkin,Irving L. Weissman,Andrew P. Feinberg,George Q. Daley +29 more
TL;DR: The authors showed that low-passage induced pluripotent stem cells (iPSCs) derived by factor-based reprogramming of adult murine tissues harbor residual DNA methylation signatures characteristic of their somatic tissue of origin.
Journal ArticleDOI
Comprehensive methylome map of lineage commitment from haematopoietic progenitors.
Hong Ji,Lauren I.R. Ehrlich,Jun Seita,Peter Murakami,Akiko Doi,Paul Lindau,Hwajin Lee,Martin J. Aryee,Rafael A. Irizarry,Kitai Kim,Derrick J. Rossi,Derrick J. Rossi,Matthew A. Inlay,Thomas Serwold,Thomas Serwold,Holger Karsunky,Lena Ho,George Q. Daley,Irving L. Weissman,Andrew P. Feinberg +19 more
TL;DR: The results directly demonstrate that modulation of DNA methylation occurs during lineage-specific differentiation and defines a comprehensive map of the methylation and transcriptional changes that accompany myeloid versus lymphoid fate decisions.
Journal ArticleDOI
NKG2D blockade prevents autoimmune diabetes in NOD mice.
Kouetsu Ogasawara,Jessica A. Hamerman,Lauren I.R. Ehrlich,Hélène Bour-Jordan,Pere Santamaria,Jeffrey A. Bluestone,Lewis L. Lanier +6 more
TL;DR: The authors showed that RAE-1 is present in prediabetic pancreas islets of NOD mice and that autoreactive CD8(+) T cells infiltrating the pancresis express NKG2D.
Journal ArticleDOI
Gene Expression Commons: an open platform for absolute gene expression profiling.
Jun Seita,Debashis Sahoo,Derrick J. Rossi,Derrick J. Rossi,Deepta Bhattacharya,Deepta Bhattacharya,Thomas Serwold,Thomas Serwold,Matthew A. Inlay,Lauren I.R. Ehrlich,John W. Fathman,David L. Dill,Irving L. Weissman +12 more
TL;DR: A very large number of varied microarray data is used as a common reference, so that statistical attributes of each probeset, such as the dynamic range and threshold between low and high expression, can be reliably discovered through meta-analysis.