Lauren J. Manderfield

TL;DR: It is shown that Hopx becomes restricted to Type I cells during development and, unexpectedly, lineage-labeled Hopx+ cells both proliferate and generate Type II cells during adult alveolar regrowth following partial pneumonectomy.

TL;DR: Using mice with primary and secondary cardiac neural crest deficiencies, it is shown that neural crest contribution to the outflow endocardial cushions (the precursors of the semilunar valves) is required for late gestation valvular remodeling, mesenchymal apoptosis, and proper valve architecture.

TL;DR: The results suggest that availability of genomic regions for activation by lineage-specific factors is regulated in part through dynamic chromatin-nuclear lamina interactions and that competence of a progenitor cell to respond to differentiation signals may depend upon coordinated movement of responding gene loci away from the nuclear periphery.

TL;DR: It is shown that Jagged1 is a direct Notch target in smooth muscle, resulting in a positive feedback loop and lateral induction that propagates a wave of smooth muscle differentiation during aortic arch artery development.

TL;DR: A specialized progenitor population that is committed exclusively to forming cardiomyocytes is identified and the mechanisms governing commitment to the myocyte lineage in vivo are identified, suggesting that Hopx promotes myogenesis by repressing Wnt signaling.