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Lauren M. Pachman
Researcher at Northwestern University
Publications - 209
Citations - 10145
Lauren M. Pachman is an academic researcher from Northwestern University. The author has contributed to research in topics: Juvenile dermatomyositis & Dermatomyositis. The author has an hindex of 55, co-authored 198 publications receiving 9319 citations. Previous affiliations of Lauren M. Pachman include Washington State University & University of Chicago.
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Journal ArticleDOI
Juvenile dermatomyositis and other idiopathic inflammatory myopathies of childhood
TL;DR: Activation of dendritic cells with upregulation of genes induced by type-1 interferon (alpha) in muscle and peripheral blood seems to be central to disease pathogenesis and treatment often includes combinations of corticosteroids, methotrexate, and other immunosuppressive agents.
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International consensus outcome measures for patients with idiopathic inflammatory myopathies. Development and initial validation of myositis activity and damage indices in patients with adult onset disease.
David A. Isenberg,Elizabeth Allen,Vernon T. Farewell,M. Ehrenstein,Michael G. Hanna,I.E. Lundberg,C. Oddis,Clarissa Pilkington,P. H. Plotz,D. L. Scott,Jiri Vencovsky,Rachel Cooper,Lisa G. Rider,Frederick W. Miller,Elizabeth Adams,Helene Alexanderson,Nancy Armentrout,Zohar Argov,Richard J. Barohn,Suzanne L. Bowyer,Hermine I. Brunner,Rubén Burgos-Vargas,Jeffrey P. Callen,Gail Cawkwell,Patrick Cherin,Yuen-Li Chung,Hanna Chwalińska-Sadowska,Robert D. Cooper,Cronin Me,Katarina Danko,Joyce Davidson,Peter B. Dent,Elizabeth M. Dugan,Brian M. Feldman,Richard Finkel,Ignacio García-De La Torre,Ekkehard Genth,Edward H. Giannini,Gerald J D Hengstman,Jeanne E. Hicks,Adam M. Huber,Hans Iko Huppertz,Lisa Imundo,Kent J. Johnson,Joseph L. Jorizzo,Lawrence Kagen,John T. Kissel,Marisa S. Klein-Gitelman,Abraham Garcia Kutzbach,Bianca Lang,Marissa Lassere,Carol B. Lindsley,Daniel J. Lovell,Sue Maillard,Peter N. Malleson,Alberto Martini,Thomas A. Medsger,Kevin J. Murray,Chester V. Oddis,Lauren M. Pachman,Amy Paller,Maria D. Perez,Paul H. Plotz,Dieter Pongratz,Angelo Ravelli,Ann M. Reed,Robert M. Rennebohm,Nicolino Ruperto,Seward Rutkove,Clyde Ryder,Jean Luc Senécal,Georges Serratrice,Jacques Serratrice,David Sherry,Kumaraswamy Sivakumar,Yeong Song,Richard D. Sontheimer,Ira N. Targoff,Maria L. Turner,Basiel van Engelen,Maria L. Villalba,Kelly Vincent,Victoria P. Werth,Patience H. White,James Witter,Robert Wortmann,Steven R. Ytterberg +86 more
TL;DR: The MITAX, MYOACT and MDI tools, which are now undergoing validity testing, should enhance the consistency, comprehensiveness and reliability of disease activity and damage assessment in patients with myositis.
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Quantification of keratan sulfate in blood as a marker of cartilage catabolism.
Eugene J.-M.A. Thonar,Mary Ellen Lenz,Gordon K. Klintworth,Bruce Caterson,Lauren M. Pachman,Paul B. Glickman,Robert S. Katz,John P. Huff,Klaus E. Kuettner +8 more
TL;DR: If the appearance of elevated levels of serumKS do indeed correlate with the extent of cartilage erosion or destruction in individuals with OA, measurements of serum KS levels will prove extremely useful in the assessment and diagnosis of this joint disease.
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Nuclear envelope dystrophies show a transcriptional fingerprint suggesting disruption of Rb–MyoD pathways in muscle regeneration
Marina Bakay,Zuyi Wang,Zuyi Wang,Gisela Melcon,Louis Schiltz,Jianhua Xuan,Po Zhao,Vittorio Sartorelli,Jinwook Seo,Jinwook Seo,Elena Pegoraro,Corrado Angelini,Ben Shneiderman,Diana M. Escolar,Yi-Wen Chen,Sara T. Winokur,Lauren M. Pachman,Chenguang Fan,Raul N. Mandler,Yoram Nevo,Erynn Gordon,Yitan Zhu,Yibin Dong,Yue Wang,Eric P. Hoffman +24 more
TL;DR: A transcriptional model for downstream consequences of LMNA and emerin mutations is developed and it is proposed that key interactions between the nuclear envelope and Rb and MyoD fail in EDMD at the point of myoblast exit from the cell cycle, leading to poorly coordinated phosphorylation and acetylation steps.
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US incidence of juvenile dermatomyositis, 1995-1998: results from the National Institute of Arthritis and Musculoskeletal and Skin Diseases Registry.
Eduardo P. Mendez,Rebecca B. Lipton,Rosalind Ramsey-Goldman,Phil Roettcher,Susan Bowyer,Alan R. Dyer,Lauren M. Pachman +6 more
TL;DR: This study provides evidence for sex, and possibly racial differences in the risk of juvenile DM in the US and suggests girls were affected more than boys during the 4-year period of the study.