C
Cyrille Confavreux
Researcher at Columbia University
Publications - 20
Citations - 3330
Cyrille Confavreux is an academic researcher from Columbia University. The author has contributed to research in topics: Medicine & Osteocalcin. The author has an hindex of 5, co-authored 7 publications receiving 3064 citations. Previous affiliations of Cyrille Confavreux include University of Lyon.
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Journal ArticleDOI
Endocrine Regulation of Energy Metabolism by the Skeleton
Na Kyung Lee,Hideaki Sowa,Eiichi Hinoi,Mathieu Ferron,Jong Deok Ahn,Cyrille Confavreux,Romain Dacquin,Patrick J. Mee,Marc D. McKee,Dae Young Jung,Zhiyou Zhang,Jason K. Kim,Franck Mauvais-Jarvis,Patricia Ducy,Gerard Karsenty +14 more
TL;DR: It is shown that mice lacking the protein tyrosine phosphatase OST-PTP are hypoglycemic and are protected from obesity and glucose intolerance because of an increase in beta-cell proliferation, insulin secretion, and insulin sensitivity, and in vivo osteocalcin can improve glucose tolerance.
Journal ArticleDOI
A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure.
Vijay K. Yadav,Franck Oury,Nina Suda,Zhong-Wu Liu,Xiao-Bing Gao,Cyrille Confavreux,Kristen C. Klemenhagen,Kenji F. Tanaka,Kenji F. Tanaka,Jay A. Gingrich,X. Edward Guo,Laurence H. Tecott,J. John Mann,René Hen,Tamas L. Horvath,Gerard Karsenty +15 more
TL;DR: This study modifies the map of leptin signaling in the brain and identifies a molecular basis for the common regulation of bone and energy metabolisms.
Journal ArticleDOI
A paradigm of integrative physiology, the crosstalk between bone and energy metabolisms
TL;DR: Bone can now be considered as a true endocrine organ secreting osteocalcin, a hormone pharmacologically active on glucose and fat metabolism which offers novel therapeutic targets in type 2 diabetes and osteoporosis.
Journal ArticleDOI
Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis
Franck Oury,Mathieu Ferron,Wang Huizhen,Cyrille Confavreux,Lin Xu,Julie Lacombe,Prashanth Srinivas,Alexandre Chamouni,Francesca Lugani,Hervé Lejeune,T. Rajendra Kumar,Ingrid Plotton,Gerard Karsenty +12 more
TL;DR: Using mouse models, this study uncovers the existence of a second endocrine axis that is necessary for optimal male fertility in the mouse and suggests that osteocalcin modulates reproductive function in humans.
Journal ArticleDOI
Osteoid osteoma is an osteocalcinoma affecting glucose metabolism
Cyrille Confavreux,Cyrille Confavreux,O. Borel,F. Lee,G. Vaz,M. Guyard,C. Fadat,M.-C. Carlier,Roland Chapurlat,Gerard Karsenty +9 more
TL;DR: It is shown for the first time that osteocalcin in humans affects blood glucose level and suggests that ostoid osteoma may be considered, at least in part, as an osteoccinoma.