Early angiotensin-converting enzyme inhibition in Alport syndrome delays renal failure and improves life expectancy
Oliver Gross,Christoph Licht,Hans J. Anders,Bernd Hoppe,Bodo B. Beck,Burkhard Tönshoff,Britta Höcker,Simone Wygoda,Jochen H. H. Ehrich,Lars Pape,Martin Konrad,Wolfgang Rascher,Jörg Dötsch,Dirk E. Müller-Wiefel,Peter F. Hoyer,Bertrand Knebelmann,Yves Pirson,Jean-Pierre Grünfeld,Patrick Niaudet,Pierre Cochat,Laurence Heidet,Said Lebbah,Roser Torra,Tim Friede,Katharina Lange,Gerhard A. Müller,Manfred Weber +26 more
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TLDR
Alport syndrome is treatable with angiotensin-converting enzyme inhibition to delay renal failure and therapy improves life expectancy in a time-dependent manner and supports the need for early diagnosis and early nephroprotective therapy in oligosymptomatic patients.About:
This article is published in Kidney International.The article was published on 2012-03-01 and is currently open access. It has received 262 citations till now. The article focuses on the topics: Renal replacement therapy & Alport syndrome.read more
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Journal ArticleDOI
Expert Guidelines for the Management of Alport Syndrome and Thin Basement Membrane Nephropathy
TL;DR: The recommendations include the use of genetic testing as the gold standard for the diagnosis of Alport syndrome and the demonstration of its mode of inheritance.
Journal ArticleDOI
Alport syndrome—insights from basic and clinical research
TL;DR: The latest basic and clinical research on Alport syndrome is discussed, focusing on the roles of podocyte pathology and the extracellular matrix, and early diagnosis and treatment options for young patients with this disorder are highlighted.
Journal ArticleDOI
Collagen (COL4A) mutations are the most frequent mutations underlying adult focal segmental glomerulosclerosis
Christine Gast,Reuben J. Pengelly,Matthew Lyon,David J. Bunyan,Eleanor G. Seaby,Nikki Graham,Gopalakrishnan Venkat-Raman,Sarah Ennis +7 more
TL;DR: It is shown that collagen IV mutations, including COL4A5, frequently underlie FSGS and should be considered, particularly with a positive family history, as well as in patients with a history of renal disease.
Journal ArticleDOI
Alport syndrome: a unified classification of genetic disorders of collagen IV α345: a position paper of the Alport Syndrome Classification Working Group.
Clifford E. Kashtan,Jie Ding,Guido Garosi,Laurence Heidet,Laura Massella,Koichi Nakanishi,Kandai Nozu,Alessandra Renieri,Michelle N. Rheault,Fang Wang,Oliver Gross +10 more
TL;DR: A new classification of genetic disorders of the collagen IV α345 molecule is proposed with the goal of improving renal outcomes through regular monitoring and early treatment.
Journal ArticleDOI
The glomerular basement membrane as a barrier to albumin
Jung Hee Suh,Jeffrey H. Miner +1 more
TL;DR: Findings from genetic studies in mice and discoveries of four human mutations affecting GBM components in two inherited kidney disorders, Alport syndrome and Pierson syndrome, support essential roles for the GBM in glomerular permselectivity.
References
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Prevalence of Chronic Kidney Disease in the United States
Josef Coresh,Elizabeth Selvin,Lesley A. Stevens,Jane Manzi,John W. Kusek,Paul W. Eggers,Frederick Van Lente,Andrew S. Levey +7 more
TL;DR: The prevalence of CKD in the United States in 1999-2004 is higher than it was in 1988-1994 and this increase is partly explained by the increasing prevalence of diabetes and hypertension and raises concerns about future increased incidence of kidney failure and other complications.
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Blood Pressure and End-Stage Renal Disease in Men
Michael J. Klag,Paul K. Whelton,Bryan L. Randall,James D. Neaton,Frederick L. Brancati,Charles E. Ford,Neil B. Shulman,Jeremiah Stamler +7 more
TL;DR: Elevations of blood pressure are a strong independent risk factor for end-stage renal disease; interventions to prevent the disease need to emphasize the prevention and control of both high-normal and high blood pressure.
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Randomised placebo-controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non-diabetic nephropathy
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Piero Ruggenenti,Anna Fassi,Anelja Parvanova Ilieva,Simona Bruno,Ilian Iliev,Varusca Brusegan,Nadia Rubis,Giulia Gherardi,Federica Arnoldi,Maria Ganeva,Bogdan Ene-Iordache,Flavio Gaspari,Annalisa Perna,Antonio Bossi,Roberto Trevisan,Alessandro Roberto Dodesini,Giuseppe Remuzzi +16 more
TL;DR: In subjects with type 2 diabetes and hypertension but with normoalbuminuria, the use of trandolapril plus verapamil and trandOLapril alone decreased the incidence of micro Albuminuria to a similar extent to that of placebo.
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