Jochen H. H. Ehrich

TL;DR: The establishment of a reproducible, high resolution method for peptidome analysis of naturally occurring human urinary peptides and proteins, ranging from 800 to 17,000 Da, using samples from 3,600 individuals analyzed by capillary electrophoresis coupled to MS is reported.

TL;DR: It is argued that clinical proteomics is not just a collection of studies dealing with analysis of clinical samples, but should be to address clinically relevant questions and to improve the state-of-the‐art, both in diagnosis and in therapy of diseases.

TL;DR: It is asserted that successful studies generally use suitable statistical approaches for biomarker definition and confirm results in independent test sets and a brief set of practical and feasible recommendations are described for investigators to properly identify and qualify proteomic biomarkers, which could also be used as reporting requirements.

TL;DR: It is concluded that SGLT2 plays an important role in renal tubular glucose reabsorption and Inheritance of renal glucosuria shows characteristics of a codominant trait with variable penetrance.

TL;DR: Alport syndrome is treatable with angiotensin-converting enzyme inhibition to delay renal failure and therapy improves life expectancy in a time-dependent manner and supports the need for early diagnosis and early nephroprotective therapy in oligosymptomatic patients.