L
Laust Bruun Johnsen
Researcher at Novo Nordisk
Publications - 19
Citations - 298
Laust Bruun Johnsen is an academic researcher from Novo Nordisk. The author has contributed to research in topics: Factor X & Mink. The author has an hindex of 5, co-authored 19 publications receiving 198 citations.
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Journal ArticleDOI
Purification and characterization of a new recombinant factor VIII (N8).
Lars Thim,Brian Berg Stidsen Vandahl,Johan Karlsson,Niels Kristian Klausen,J. Pedersen,Thomas N. Krogh,Marianne Kjalke,J. M. Petersen,Laust Bruun Johnsen,Gert Bolt,Peder Lisby Nørby,Thomas Dock Steenstrup +11 more
TL;DR: The present data show that N8 is a pure and well‐characterized FV III product with biochemical properties that equal other FVIII products.
Journal ArticleDOI
The SARS-CoV-2 Y453F mink variant displays a pronounced increase in ACE-2 affinity but does not challenge antibody neutralization.
Rafael Bayarri-Olmos,Anne Rosbjerg,Laust Bruun Johnsen,Charlotte Helgstrand,Theresa Bak-Thomsen,Peter Garred,Mikkel-Ole Skjoedt +6 more
TL;DR: In this paper, the authors present functional data on the cluster-five variant, which contains a mutation resulting in a Y453F residue change in the receptor-binding domain (RBD) of the spike protein.
Journal ArticleDOI
SARS-CoV-2 Neutralizing Antibody Responses towards Full-Length Spike Protein and the Receptor-Binding Domain.
Rafael Bayarri-Olmos,Manja Idorn,Anne Rosbjerg,Laura Pérez-Alós,Cecilie Bo Hansen,Laust Bruun Johnsen,Charlotte Helgstrand,Franziska Zosel,Jais Rose Bjelke,Fredrik Kryh Öberg,Max Søgaard,Søren R. Paludan,Theresa Bak-Thomsen,Joseph G. Jardine,Mikkel-Ole Skjoedt,Peter Garred +15 more
TL;DR: In this paper, a neutralization ELISA was used to determine the levels of Ab-mediated virus neutralization and a preclinical model of focused immunization strategy was presented to monitor SARS-CoV-2 transmission and immune responses.
Journal ArticleDOI
A factor VIIIa-mimetic bispecific antibody, Mim8, ameliorates bleeding upon severe vascular challenge in hemophilia A mice.
Henrik Østergaard,Jacob Lund,Per Jr Greisen,Stine Kjellev,A. Henriksen,Nikolai Lorenzen,Eva Johansson,Gustav Røder,Morten Grønbech Rasch,Laust Bruun Johnsen,Thomas Egebjerg,Søren Lund,Henrik Rahbek-Nielsen,Prafull S. Gandhi,Kasper Lamberth,Mette Loftager,Lisbeth Moreau Andersen,Amalie Carnbring Bonde,Fabian Stavenuiter,Daniel Elenius Madsen,Xun Li,Thomas Lindebo Holm,Carsten Dan Ley,Peter Thygesen,Haisun Zhu,Rong Zhou,Karina Thorn,Zhiru Yang,Mette B. Hermit,Jais Rose Bjelke,Bjarne Gram Hansen,Ida Hilden +31 more
TL;DR: Mim8 as mentioned in this paper is an activated FVIII mimetic with a potent and efficacious hemostatic effect based on preclinical data, which is a bispecific antibody assembled with FIXa and FX on membranes, and supported activation with an apparent equilibrium dissociation constant of 16 nM.
Journal ArticleDOI
Functional Effects of Receptor-Binding Domain Mutations of SARS-CoV-2 B.1.351 and P.1 Variants.
Rafael Bayarri-Olmos,Ida Jarlhelt,Laust Bruun Johnsen,Cecilie Bo Hansen,Charlotte Helgstrand,Jais Rose Bjelke,Finn Matthiesen,Susanne Dam Nielsen,Kasper Iversen,Kasper Iversen,Sisse R. Ostrowski,Henning Bundgaard,Ruth Frikke-Schmidt,Peter Garred,Peter Garred,Mikkel-Ole Skjoedt,Mikkel-Ole Skjoedt +16 more
TL;DR: In this article, the functional and immune evasive consequences of the P.1 and B.1.351 RBD mutations were characterized, and the results suggest that the combination of these three mutations is a two-step forward and one step back in terms of viral fitness.