L
Lazaros C. Foukas
Researcher at University College London
Publications - 21
Citations - 2279
Lazaros C. Foukas is an academic researcher from University College London. The author has contributed to research in topics: MAP kinase kinase kinase & MAP2K7. The author has an hindex of 16, co-authored 21 publications receiving 2092 citations. Previous affiliations of Lazaros C. Foukas include Queen Mary University of London & Ludwig Institute for Cancer Research.
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Journal ArticleDOI
Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration
Mariona Graupera,Julie Guillermet-Guibert,Lazaros C. Foukas,Li-Kun Phng,Robert J. Cain,Ashreena Salpekar,Wayne Pearce,Stephen Meek,Jaime Millan,Pedro R. Cutillas,Andrew J.H. Smith,Anne J. Ridley,Christiana Ruhrberg,Holger Gerhardt,Bart Vanhaesebroeck +14 more
TL;DR: It is shown that only p110α activity is essential for vascular development and the first in vivo evidence for p110-isoform selectivity in endothelial PI3K signalling during angiogenesis is provided.
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Signalling by PI3K isoforms: insights from gene-targeted mice.
Bart Vanhaesebroeck,Khaled Ali,Khaled Ali,Antonio Bilancio,Barbara Geering,Barbara Geering,Lazaros C. Foukas +6 more
TL;DR: Gene-targeting studies in the mouse have recently uncovered key roles for specific PI3K isoforms in immunity, metabolism and cardiac function, and targeting strategies that take into account the complex interplay between members of thePI3K family will be crucial to gain a full understanding of the physiological roles of the isoforms of PI3k.
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Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation
Lazaros C. Foukas,Marc Claret,Wayne Pearce,Klaus Okkenhaug,Klaus Okkenhaug,Stephen Meek,Emma Peskett,Sara Sancho,Andrew J.H. Smith,Dominic J. Withers,Bart Vanhaesebroeck,Bart Vanhaesebroeck +11 more
TL;DR: A critical role for p110 α in growth factor and metabolic signalling is demonstrated and an explanation for selective mutation or overexpression of p110α in a variety of cancers is suggested.
Journal ArticleDOI
Activity of any class IA PI3K isoform can sustain cell proliferation and survival
TL;DR: In this article, the role of class I PI3K isoforms in cell proliferation and survival was assessed in immortalized mouse leukocyte and fibroblast models, in which all four isoforms were inactivated by genetic and pharmacological approaches.
Journal ArticleDOI
Direct effects of caffeine and theophylline on p110 delta and other phosphoinositide 3-kinases. Differential effects on lipid kinase and protein kinase activities.
Lazaros C. Foukas,Nathalie Daniele,Chariklia Ktori,Karen E. Anderson,Jørgen Jensen,Peter R. Shepherd +5 more
TL;DR: Results demonstrate that these methylxanthines are direct inhibitors of PI3K lipid kinase activity but are distinctly less effective against serine kinaseActivity and thus could be of potential use in dissecting these two distinct kinase activities.