M
Mariona Graupera
Researcher at Carlos III Health Institute
Publications - 72
Citations - 5441
Mariona Graupera is an academic researcher from Carlos III Health Institute. The author has contributed to research in topics: Angiogenesis & PI3K/AKT/mTOR pathway. The author has an hindex of 31, co-authored 60 publications receiving 4381 citations. Previous affiliations of Mariona Graupera include University of Barcelona & Queen Mary University of London.
Papers
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Journal ArticleDOI
The emerging mechanisms of isoform-specific PI3K signalling
TL;DR: A better understanding of how the different PI3K isoforms are regulated and control signalling could uncover their roles in pathology and reveal in which disease contexts their blockade could be most beneficial.
Journal ArticleDOI
Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration
Mariona Graupera,Julie Guillermet-Guibert,Lazaros C. Foukas,Li-Kun Phng,Robert J. Cain,Ashreena Salpekar,Wayne Pearce,Stephen Meek,Jaime Millan,Pedro R. Cutillas,Andrew J.H. Smith,Anne J. Ridley,Christiana Ruhrberg,Holger Gerhardt,Bart Vanhaesebroeck +14 more
TL;DR: It is shown that only p110α activity is essential for vascular development and the first in vivo evidence for p110-isoform selectivity in endothelial PI3K signalling during angiogenesis is provided.
Journal ArticleDOI
Simvastatin treatment improves liver sinusoidal endothelial dysfunction in CCl4 cirrhotic rats.
Juan G. Abraldes,Aina Rodríguez-Vilarrupla,Mariona Graupera,Carmen Zafra,Héctor García-Calderó,Juan Carlos García-Pagán,Jaime Bosch +6 more
TL;DR: In isolated and perfused cirrhotic livers simvastatin pre-treatment significantly attenuated the pressure response to methoxamine, and significantly improved paradoxical vasoconstriction induced by acetylcholine.
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cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels
Lukas Stanczuk,Lukas Stanczuk,Ines Martinez-Corral,Ines Martinez-Corral,Maria H. Ulvmar,Yang Zhang,Barbbara Lavina,Marcus Fruttiger,Ralf H. Adams,Dieter Saur,Dieter Saur,Christer Betsholtz,Christer Betsholtz,Sagrario Ortega,Kari Alitalo,Mariona Graupera,Taija Makinen,Taija Makinen +17 more
TL;DR: It is shown that the vascular endothelial growth factor receptor 3/p110α PI3-kinase signaling pathway is selectively required for the formation of mesenteric lymphatic vasculature, which may critically underlie organ-specific manifestation of lymphatic dysfunction in disease.
Journal ArticleDOI
Targeting Pi3k In Cancer: Impact on Tumor Cells, Their Protective Stroma, Angiogenesis, and Immunotherapy
TL;DR: It is proposed that PI3K isoform-selective inhibitors may be exploited in the context of cancer immunotherapy and by targeting angiogenesis to improve drug and immune cell delivery.