L
Lei Ding
Researcher at Columbia University
Publications - 38
Citations - 6158
Lei Ding is an academic researcher from Columbia University. The author has contributed to research in topics: Stem cell & Haematopoiesis. The author has an hindex of 19, co-authored 31 publications receiving 5006 citations. Previous affiliations of Lei Ding include University of Colorado Boulder & University of Texas Southwestern Medical Center.
Papers
More filters
Journal ArticleDOI
Endothelial and perivascular cells maintain haematopoietic stem cells
TL;DR: HSCs reside in a perivascular niche in which multiple cell types express factors that promote HSC maintenance, and were depleted from bone marrow when Scf was deleted from endothelial cells or leptin receptor (Lepr)-expressing periv vascular stromal cells.
Journal ArticleDOI
Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches
Lei Ding,Sean J. Morrison +1 more
TL;DR: Assessment of the physiological sources of the chemokine CXCL12 for HSC and restricted progenitor maintenance shows that Cxcl12 was primarily expressed by perivascular stromal cells and, at lower levels, by endothelial cells, osteoblasts and some haematopoietic cells.
Journal ArticleDOI
SLAM Family Markers Resolve Functionally Distinct Subpopulations of Hematopoietic Stem Cells and Multipotent Progenitors
TL;DR: Four SLAM family markers, CD150, CD48, CD229, and CD244, can distinguish HSCs and MPPs from restricted progenitors and subdivide them into a hierarchy of functionally distinct subpopulations with stepwise changes in cell-cycle status, self-renewal, and reconstituting potential.
Journal ArticleDOI
The Developmental Timing Regulator AIN-1 Interacts with miRISCs and May Target the Argonaute Protein ALG-1 to Cytoplasmic P Bodies in C. elegans
TL;DR: The results suggest a model where AIN-1 regulates a subset of miRISCs by localization to the processing bodies, facilitating degradation or translational inhibition of mRNA targets.
Journal ArticleDOI
Hematopoietic Stem Cells Are the Major Source of Multilineage Hematopoiesis in Adult Animals.
Catherine M. Sawai,Sonja Babovic,Samik Upadhaya,Samik Upadhaya,David J.H.F. Knapp,Yonit Lavin,Colleen M. Lau,Anton Goloborodko,Jue Feng,Joji Fujisaki,Lei Ding,Leonid A. Mirny,Miriam Merad,Connie J. Eaves,Boris Reizis,Boris Reizis +15 more
TL;DR: The authors showed that transgene-expressing HSCs gave rise to other phenotypic HSC cells, confirming their top position in the differentiation hierarchy, but not to B-1a cells or tissue macrophages.