Lei Wei

TL;DR: The results indicated that CU alleviated the hepatic histopathological damages induced by cisplatin, which included declined body weight, vacuolated cytoplasm and blurred liver trabecular structure.

TL;DR: The data suggested that Osthole increases the catabolism of rat chondrocytes and cartilage explants, this effect might be mediated through inhibiting Wnt7b/β-catenin pathway.

TL;DR: Wnt1 promoted EAAT2 expression and mediated the cytoprotective effects of astrocytes on dopaminergic cells, and NF-κB might be involved in the regulation ofEAAT2 by Wnt1.

TL;DR: During onset of osteoarthrosis the synthesis of large proteoglycans gradually becomes insufficient to compensate for the simultaneous degradation, which differs from findings in more rapidly progressing, experimental secondary osteOarthrosis, where a substantial increase in the rate of degradation is more conspicuous.

TL;DR: Understanding the role of HDAC4 during chondrocyte hypertrophy and endochondral bone formation and its features regarding the structure, function, and regulation of this process will not only provide new insight into the mechanisms by whichHDAC4 is involved in chondrosclerosis, but will also create a platform for developing a therapeutic strategy for related diseases.