L
Lei Wei
Researcher at Wuhan University
Publications - 320
Citations - 13830
Lei Wei is an academic researcher from Wuhan University. The author has contributed to research in topics: Cartilage & Osteoarthritis. The author has an hindex of 57, co-authored 304 publications receiving 11840 citations. Previous affiliations of Lei Wei include Rhode Island Hospital & Brown University.
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Journal ArticleDOI
Rnd3 haploinsufficient mice are predisposed to hemodynamic stress and develop apoptotic cardiomyopathy with heart failure.
Xiaojing Yue,Xiangsheng Yang,Xi Lin,Tingli Yang,Xin Yi,Yuan Dai,J. Guo,Tao Li,Jianjian Shi,Lei Wei,Guo-Chang Fan,C. Chen,Jiang Chang +12 more
TL;DR: In this article, a double-knockout mouse line, the Rnd3 haploinsufficient mice with ROCK1-null background (Rnd3+/−/ROCK1−/−).
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Dissecting the roles of ROCK isoforms in stress-induced cell detachment
TL;DR: These studies further support the differential roles of ROCK isoforms in regulating stress-induced loss of central stress fibers and focal adhesions as well as cell detachment and add new insights into a novel mechanism underlying the anti-detachment effects of ROCK1 deletion.
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Irisin counteracts high glucose and fatty acid-induced cytotoxicity by preserving the AMPK-insulin receptor signaling axis in C2C12 myoblasts.
Naohiro Yano,Ling Zhang,Dennis Wei,Patrycja M. Dubielecka,Lei Wei,Shougang Zhuang,Ping Zhu,Gangjian Qin,Paul Y. Liu,Y. Eugene Chin,Ting C. Zhao +10 more
TL;DR: The results indicate that irisin counteracts to the stresses generated by high glucose and fatty acid and serves as a novel approach to eliciting cellular protection.
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Tumor suppressor berberine binds VASP to inhibit cell migration in basal-like breast cancer.
Ke Su,Peng-Chao Hu,Xiaolan Wang,Chang-Chun Kuang,Qingmin Xiang,Fang Yang,Jin Xiang,Shan Zhu,Lei Wei,Jingwei Zhang +9 more
TL;DR: The mechanism underlying berberine's inhibition of cell proliferation and migration in basal-like breast cancer is revealed, highlighting the use of berberines as a potential adjuvant therapeutic agent.
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Deletion of estrogen receptor beta accelerates early stage of bone healing in a mouse osteotomy model.
Yixin He,Z. Liu,Xiaohua Pan,Tao Tang,Baosheng Guo,Lizhen Zheng,Xinhui Xie,Xinluan Wang,Xinluan Wang,Kwong Man Lee,Gang Li,Y. P. Cao,Lei Wei,Lei Wei,Y. Chen,Zhijun Yang,Leung-Kim Hung,Ling Qin,Ling Qin,Ge Zhang +19 more
TL;DR: The fracture healing in KO mice was enhanced in the early stage of neovascularization and the middle stage of endochondral ossification, but not by the end of healing, which can be considered as another therapeutic strategy for osteoporotic fracture and non-union fracture.