Lei Wei

TL;DR: The findings elucidated the morphological mechanism that the exposure of cadmium changed the ultrastructure of cells in ovary tissues and clarified the cytotoxicity and pathological effects of Cadmium on the ovary.

TL;DR: The decreased level of IGF-1 may play a critical role for maintaining the balance between catabolic and anabolic processes in cartilage metabolism during the development of osteoarthritis, which may be applicable to developing OA therapy.

TL;DR: Gene structure and DNA methylation analysis results indicated that MAGI2‐AS3 may act as a cis‐acting regulatory element downregulating theDNA methylation level of the MAGI 2 promoter region, and the DNA demethylase TET1 inhibitor can reverse MAGI1‐ AS3 overexpression caused upregulation of MAGI3 and cellular effects.

TL;DR: The data suggested that Wnt/β-catenin and Nurr1 are crucial factors in the survival of DA neurons, and the activation of Wnt-β-Catenin pathway exerts protective effects on DA neurons partly by mean of a co-active pattern with Nurr 1.

TL;DR: Results reveal that exendin-4 treatment improves cardiac function, attenuates cardiac remodeling, and promotes angiogenesis in the infarcted myocardium through MKK3 and Akt-1 pathway.