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Lei Wei

Researcher at Wuhan University

Publications -  320
Citations -  13830

Lei Wei is an academic researcher from Wuhan University. The author has contributed to research in topics: Cartilage & Osteoarthritis. The author has an hindex of 57, co-authored 304 publications receiving 11840 citations. Previous affiliations of Lei Wei include Rhode Island Hospital & Brown University.

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Journal ArticleDOI

β1-Integrin and PI 3-kinase regulate RhoA-dependent activation of skeletal α-actin promoter in myoblasts

Lei Wei, +3 more
- 01 Jun 2000 - 
TL;DR: RhoA GTPase, a regulator of actin cytoskeleton, is also involved in regulating c-fos gene expression through its effect on serum response factor (SRF) transcriptional activity.
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Reduced limb length and worsened osteoarthritis in adult mice after genetic inhibition of p38 MAP kinase activity in cartilage.

Surena Namdari, +4 more
- 01 Nov 2008 - 
TL;DR: The findings demonstrate that chronic life-long reduction of p38 MAPK activity may be harmful to joint health and suggest that the timing of p 38 inhibition for chondroprotection in vivo is an important variable that warrants further investigation.
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Direct Renin Inhibition With Aliskiren Protects Against Myocardial Ischemia/Reperfusion Injury by Activating Nitric Oxide Synthase Signaling in Spontaneously Hypertensive Rats

Wen Zhang, +12 more
- 28 Jan 2014 - 
TL;DR: Direct renin inhibition protects against myocardial I/R injury through activation of the PI3K‐Akt‐eNOS pathway.
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Contribution of IL-1β, 6 and TNF-α to the form of post-traumatic osteoarthritis induced by "idealized" anterior cruciate ligament reconstruction in a porcine model.

Pengfei Han, +10 more
- 11 Oct 2018 - 
TL;DR: Inflammatory factors are independently responsible for the onset of PTOA and a close relationship was found between IL‐1&bgr;, IL‐6 and TNF‐&agr; concentrations and morphological score of PtoA, respectively.
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ROCK1 functions as a critical regulator of stress erythropoiesis and survival by regulating p53

Sasidhar Vemula, +9 more
- 18 Nov 2011 - 
TL;DR: The findings reveal that ROCK1 functions as a physiologic regulator of p53 under conditions of erythroid stress and may provide a potential therapeutic target in human disease characterized by anemia.