L
Leila E. Mansoor
Researcher at Centre for the AIDS Programme of Research in South Africa
Publications - 49
Citations - 3903
Leila E. Mansoor is an academic researcher from Centre for the AIDS Programme of Research in South Africa. The author has contributed to research in topics: Medicine & Pre-exposure prophylaxis. The author has an hindex of 15, co-authored 34 publications receiving 3575 citations. Previous affiliations of Leila E. Mansoor include National Institutes of Health.
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Journal ArticleDOI
Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women
Quarraisha Abdool Karim,Salim S. Abdool Karim,Salim S. Abdool Karim,Salim S. Abdool Karim,Janet A. Frohlich,Anneke Grobler,Cheryl Baxter,Leila E. Mansoor,Ayesha B. M. Kharsany,Sengeziwe Sibeko,Koleka Mlisana,Zaheen Omar,Tanuja N. Gengiah,Silvia Maarschalk,Natasha Arulappan,Mukelisiwe Mlotshwa,Lynn Morris,Douglas Taylor +17 more
TL;DR: Tenofovir in a vaginal gel formulation shows significant protection against HIV infection in a randomized control trial, and could potentially fill an important HIV prevention gap, especially for women unable to successfully negotiate mutual monogamy or condom use.
Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women: Supporting Online Material
Journal ArticleDOI
Genital Inflammation and the Risk of HIV Acquisition in Women
Lindi Masson,Lindi Masson,Jo-Ann S. Passmore,Jo-Ann S. Passmore,Lenine J. P. Liebenberg,Lise. Werner,Cheryl Baxter,Kelly B. Arnold,Carolyn Williamson,Carolyn Williamson,Francesca Little,Leila E. Mansoor,Vivek Naranbhai,Douglas A. Lauffenburger,Katharina Ronacher,Gerhard Walzl,Nigel Garrett,Brent L. Williams,Mara Couto-Rodriguez,Mady Hornig,W. Ian Lipkin,Anneke Grobler,Quarraisha Abdool Karim,Quarraisha Abdool Karim,Salim S. Abdool Karim,Salim S. Abdool Karim +25 more
TL;DR: Elevated genital concentrations of HIV target cell-recruiting chemokines and a genital inflammatory profile contributes to the high risk of HIV acquisition in these African women.
Journal ArticleDOI
Adherence Support Approaches in Biomedical HIV Prevention Trials: Experiences, Insights and Future Directions from Four Multisite Prevention Trials
K. Rivet Amico,Leila E. Mansoor,Amy Corneli,Kristine Torjesen,Ariane van der Straten,Ariane van der Straten +5 more
TL;DR: Recommendations from across these trials include participant-centered approaches, separating measurement of adherence from adherence counseling, incorporating tailored strategies that go beyond education, fostering motivation, and addressing the specific context in which an individual incorporates and negotiates PrEP use.
Journal ArticleDOI
Genital inflammation undermines the effectiveness of tenofovir gel in preventing HIV acquisition in women.
Lyle R. McKinnon,Lyle R. McKinnon,Lyle R. McKinnon,Lenine J. P. Liebenberg,Lenine J. P. Liebenberg,Nonhlanhla Yende-Zuma,Derseree Archary,Derseree Archary,Sinaye Ngcapu,Sinaye Ngcapu,Aida Sivro,Aida Sivro,Aida Sivro,Nico J. D. Nagelkerke,Jose Gerardo Garcia Lerma,Angela D. M. Kashuba,Lindi Masson,Lindi Masson,Leila E. Mansoor,Quarraisha Abdool Karim,Quarraisha Abdool Karim,Salim S. Abdool Karim,Salim S. Abdool Karim,Jo-Ann S. Passmore,Jo-Ann S. Passmore,Jo-Ann S. Passmore +25 more
TL;DR: A post hoc prospective analysis of results from the CAPRISA 004 trial for 1% tenofovir gel, one of the first trials to demonstrate protection against HIV infection, found that reducing genital inflammation in women may augment HIV prevention efforts.