Léo Freitas-Correa

TL;DR: Results reveal pathogenic mechanisms shared by AD and diabetes and establish that proinflammatory signaling mediates oligomer-induced IRS-1 inhibition and PKR-dependent synapse and memory loss.

TL;DR: Investigation of changes in transcription in adult human cortical slices exposed to sublethal doses of AβOs establishes early mechanisms involved in AβO-triggered neuronal dysfunction in a novel human-derived experimental model and suggests that the neuronal pathways affected by A βOs may be targets for the development of novel diagnostic or therapeutic approaches.

TL;DR: DNA microarray analysis is used to investigate changes in gene expression in rat hippocampal neurons in culture treated with low micromolar concentrations of DNP, shedding light on molecular mechanisms underlying neuroprotection by DNP and point to possible targets for development of novel therapeutics for neurodegenerative disorders.

TL;DR: It is established that D NP induces neural differentiation of ESCs, accompanied by cell proliferation, migration and neuritogenesis, suggesting that DNP may be a novel tool to induce neurogenesis in embryonic stem cells.