J
Jean-Christophe Houzel
Researcher at Federal University of Rio de Janeiro
Publications - 30
Citations - 2226
Jean-Christophe Houzel is an academic researcher from Federal University of Rio de Janeiro. The author has contributed to research in topics: Insulin receptor & Dopaminergic. The author has an hindex of 19, co-authored 30 publications receiving 1936 citations. Previous affiliations of Jean-Christophe Houzel include Collège de France & Max Planck Society.
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Journal ArticleDOI
An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers
Theresa R. Bomfim,Leticia Forny-Germano,Luciana B. Sathler,Jordano Brito-Moreira,Jean-Christophe Houzel,Helena Decker,Helena Decker,Michael A. Silverman,Hala Kazi,Helen M. Melo,Paula McClean,Christian Hölscher,Steven E. Arnold,Konrad Talbot,William L. Klein,Douglas P. Munoz,Sergio T. Ferreira,Fernanda G. De Felice +17 more
TL;DR: It is shown that serine phosphorylation of IRS-1 (IRS-1pSer) is common to both diseases, and establishes molecular links between the dysregulated insulin signaling in AD and diabetes.
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TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys
Mychael V. Lourenco,Julia R. Clarke,Rudimar Luiz Frozza,Theresa R. Bomfim,Leticia Forny-Germano,Andre F. Batista,Luciana B. Sathler,Jordano Brito-Moreira,Olavo B. Amaral,Cesar A. Silva,Léo Freitas-Correa,Sheila Espírito-Santo,Paula Campello-Costa,Jean-Christophe Houzel,William L. Klein,Christian Hölscher,José B.C. Carvalheira,Aristóbolo M. Silva,Aristóbolo M. Silva,Licio A. Velloso,Douglas P. Munoz,Sergio T. Ferreira,Fernanda G. De Felice +22 more
TL;DR: Results reveal pathogenic mechanisms shared by AD and diabetes and establish that proinflammatory signaling mediates oligomer-induced IRS-1 inhibition and PKR-dependent synapse and memory loss.
Journal ArticleDOI
Alzheimer's Disease-Like Pathology Induced by amyloid-β Oligomers in Nonhuman Primates
Leticia Forny-Germano,Natalia M. Lyra e Silva,Andre F. Batista,Jordano Brito-Moreira,Matthias Gralle,Susan E. Boehnke,Brian C. Coe,Ann Lablans,Suelen Adriani Marques,Ana Maria Blanco Martinez,William L. Klein,Jean-Christophe Houzel,Sergio T. Ferreira,Douglas P. Munoz,Fernanda G. De Felice +14 more
TL;DR: Generation of a macaque model of AD that links Aβ oligomers to tau and synaptic pathology has the potential to greatly advance the understanding of mechanisms centrally implicated in AD pathogenesis.
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The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of Alzheimer's disease
Andre F. Batista,Leticia Forny-Germano,Julia R. Clarke,Natalia M. Lyra e Silva,Jordano Brito-Moreira,Susan E. Boehnke,Andrew Winterborn,Brian C. Coe,Ann Lablans,Juliana F.S. Vital,Suelen Adriani Marques,Ana Maria Blanco Martinez,Matthias Gralle,Christian Hölscher,William L. Klein,Jean-Christophe Houzel,Sergio T. Ferreira,Douglas P. Munoz,Fernanda G. De Felice,Fernanda G. De Felice +19 more
TL;DR: It is shown that liraglutide prevented the loss of brain insulin receptors and synapses, and reversed memory impairment induced by AD‐linked amyloid‐β oligomers (AβOs) in mice, and indicated that GLP‐1 receptor activation may be harnessed to protect brain insulin receptor, synaptic, and tau pathology in AD.
Journal ArticleDOI
Inhibition of Alzheimer’s disease β-amyloid aggregation, neurotoxicity, and in vivo deposition by nitrophenols: implications for Alzheimer’s therapy
Fernanda G. De Felice,Jean-Christophe Houzel,José Garcia-Abreu,Paulo Roberto Louzada,Rosenilde C. de Holanda Afonso,M. Nazareth L. Meirelles,Roberto Lent,Vivaldo Moura Neto,Sergio T. Ferreira +8 more
TL;DR: It is shown that nitrophenols prevent aggregation and cause disaggregation of A β fibrils and that they strongly prevent the neurotoxicity of Aβ to rat hippocampal neurons in culture.