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Theresa R. Bomfim
Researcher at Federal University of Rio de Janeiro
Publications - 12
Citations - 2582
Theresa R. Bomfim is an academic researcher from Federal University of Rio de Janeiro. The author has contributed to research in topics: Insulin receptor & Synapse. The author has an hindex of 11, co-authored 12 publications receiving 2269 citations.
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Journal ArticleDOI
An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers
Theresa R. Bomfim,Leticia Forny-Germano,Luciana B. Sathler,Jordano Brito-Moreira,Jean-Christophe Houzel,Helena Decker,Helena Decker,Michael A. Silverman,Hala Kazi,Helen M. Melo,Paula McClean,Christian Hölscher,Steven E. Arnold,Konrad Talbot,William L. Klein,Douglas P. Munoz,Sergio T. Ferreira,Fernanda G. De Felice +17 more
TL;DR: It is shown that serine phosphorylation of IRS-1 (IRS-1pSer) is common to both diseases, and establishes molecular links between the dysregulated insulin signaling in AD and diabetes.
Journal ArticleDOI
Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers
Fernanda G. De Felice,Marcelo N. N. Vieira,Theresa R. Bomfim,Helena Decker,Pauline T. Velasco,Mary P. Lambert,Kirsten L. Viola,Wei Qin Zhao,Sergio T. Ferreira,William L. Klein +9 more
TL;DR: The finding that synapse vulnerability to ADDLs can be mitigated by insulin suggests that bolstering brain insulin signaling, which can decline with aging and diabetes, could have significant potential to slow or deter AD pathogenesis.
Journal ArticleDOI
TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys
Mychael V. Lourenco,Julia R. Clarke,Rudimar Luiz Frozza,Theresa R. Bomfim,Leticia Forny-Germano,Andre F. Batista,Luciana B. Sathler,Jordano Brito-Moreira,Olavo B. Amaral,Cesar A. Silva,Léo Freitas-Correa,Sheila Espírito-Santo,Paula Campello-Costa,Jean-Christophe Houzel,William L. Klein,Christian Hölscher,José B.C. Carvalheira,Aristóbolo M. Silva,Aristóbolo M. Silva,Licio A. Velloso,Douglas P. Munoz,Sergio T. Ferreira,Fernanda G. De Felice +22 more
TL;DR: Results reveal pathogenic mechanisms shared by AD and diabetes and establish that proinflammatory signaling mediates oligomer-induced IRS-1 inhibition and PKR-dependent synapse and memory loss.
Journal ArticleDOI
Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease
TL;DR: The concept that peripheral and central nervous system inflammation link the pathogenesis of AD and metabolic diseases is discussed and the contribution of brain inflammation to defective insulin signaling and neuronal dysfunction is explored.
Journal ArticleDOI
Alzheimer‐associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation
Julia R. Clarke,Natalia M. Lyra e Silva,Cláudia P. Figueiredo,Rudimar Luiz Frozza,Jose Henrique Ledo,Danielle Beckman,Carlos K. Katashima,Daniela S. Razolli,Bruno M. Carvalho,Renata Frazão,Marina A. Silveira,Felipe C. Ribeiro,Theresa R. Bomfim,Fernanda S Neves,William L. Klein,Rodrigo Medeiros,Frank M. LaFerla,José B.C. Carvalheira,Mario J.A. Saad,Douglas P. Munoz,Licio A. Velloso,Sergio T. Ferreira,Fernanda G. De Felice +22 more
TL;DR: It is shown that intracerebroventricular infusion of AD‐associated Aβ oligomers (AβOs) in mice triggered peripheral glucose intolerance, a phenomenon further verified in two transgenic mouse models of AD.