L
Luciana B. Sathler
Researcher at Federal University of Rio de Janeiro
Publications - 4
Citations - 1055
Luciana B. Sathler is an academic researcher from Federal University of Rio de Janeiro. The author has contributed to research in topics: Insulin receptor & Cholinergic neuron. The author has an hindex of 3, co-authored 4 publications receiving 893 citations.
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Journal ArticleDOI
An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers
Theresa R. Bomfim,Leticia Forny-Germano,Luciana B. Sathler,Jordano Brito-Moreira,Jean-Christophe Houzel,Helena Decker,Helena Decker,Michael A. Silverman,Hala Kazi,Helen M. Melo,Paula McClean,Christian Hölscher,Steven E. Arnold,Konrad Talbot,William L. Klein,Douglas P. Munoz,Sergio T. Ferreira,Fernanda G. De Felice +17 more
TL;DR: It is shown that serine phosphorylation of IRS-1 (IRS-1pSer) is common to both diseases, and establishes molecular links between the dysregulated insulin signaling in AD and diabetes.
Journal ArticleDOI
TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys
Mychael V. Lourenco,Julia R. Clarke,Rudimar Luiz Frozza,Theresa R. Bomfim,Leticia Forny-Germano,Andre F. Batista,Luciana B. Sathler,Jordano Brito-Moreira,Olavo B. Amaral,Cesar A. Silva,Léo Freitas-Correa,Sheila Espírito-Santo,Paula Campello-Costa,Jean-Christophe Houzel,William L. Klein,Christian Hölscher,José B.C. Carvalheira,Aristóbolo M. Silva,Aristóbolo M. Silva,Licio A. Velloso,Douglas P. Munoz,Sergio T. Ferreira,Fernanda G. De Felice +22 more
TL;DR: Results reveal pathogenic mechanisms shared by AD and diabetes and establish that proinflammatory signaling mediates oligomer-induced IRS-1 inhibition and PKR-dependent synapse and memory loss.
Journal ArticleDOI
Rescue of amyloid-Beta-induced inhibition of nicotinic acetylcholine receptors by a peptide homologous to the nicotine binding domain of the alpha 7 subtype
Arthur A. Nery,Margaret H. Magdesian,Cleber A. Trujillo,Luciana B. Sathler,Maria A. Juliano,Luiz Juliano,Henning Ulrich,Sergio T. Ferreira +7 more
TL;DR: Findings indicate that Aβ40 inhibits different subtypes of nAChRs by interacting with specific receptor domains homologous to the IQ peptide, suggesting that IQ may be a lead for novel drugs to block the inhibition of cholinergic function in AD.
Journal ArticleDOI
Endoplasmic reticulum stress links impaired insulin signaling and Alzheimer's disease
Mychael V. Lourenco,Cesar A. Silva,Luciana B. Sathler,Leticia Forny-Germano,Theresa R. Bomfim,Sheila Espírito Santo Araújo,Paula Campello-Costa,William L. Klein,Douglas P. Munoz,Sergio T. Ferreira,Fernanda G. De Felice +10 more
TL;DR: It is demonstrated that aggregation of the ER promotes the formation of Atg14L-Beclin1-Vps34 complex to initiate autophagy and p62 on the ER further promote clearance of damaged ER for autophagic degradation.