L
Leondios G. Kostrikis
Researcher at University of Cyprus
Publications - 86
Citations - 7580
Leondios G. Kostrikis is an academic researcher from University of Cyprus. The author has contributed to research in topics: Population & Genotype. The author has an hindex of 39, co-authored 82 publications receiving 7154 citations. Previous affiliations of Leondios G. Kostrikis include Aaron Diamond AIDS Research Center & National and Kapodistrian University of Athens.
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Effects of in vivo CD8(+) T cell depletion on virus replication in rhesus macaques immunized with a live, attenuated simian immunodeficiency virus vaccine.
Karin J. Metzner,Xia Jin,Fred Lee,Agegnehu Gettie,Daniel E. Bauer,Michele Di Mascio,Alan S. Perelson,Preston A. Marx,Preston A. Marx,David D. Ho,Leondios G. Kostrikis,Ruth I. Connor +11 more
TL;DR: The results indicate that CD8+ T cells play an important role in controlling replication of live, attenuated SIV in vivo, and were reduced by as much as 99% in the peripheral blood.
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Genetic analysis of human immunodeficiency virus type 1 strains from patients in Cyprus: identification of a new subtype designated subtype I.
TL;DR: DNA sequences encoding the C2 to V3 region of envelope glycoprotein gp120 of human immunodeficiency virus type 1 were amplified by PCR from uncultured peripheral blood mononuclear cells obtained from patients from Cyprus, demonstrating the extensive heterogeneity of HIV-1 in Cyprus, including the presence of new subtype.
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Use of Coreceptors Other Than CCR5 by Non-Syncytium-Inducing Adult and Pediatric Isolates of Human Immunodeficiency Virus Type 1 Is Rare In Vitro
Yi-jun Zhang,Tatjana Dragic,Yunzhen Cao,Leondios G. Kostrikis,Douglas S. Kwon,Dan R. Littman,Vineet N. KewalRamani,John P. Moore +7 more
TL;DR: A panel of pediatric and adult human immunodeficiency virus type 1 (HIV-1) primary isolates for the ability to employ the following proteins as coreceptors during viral entry found that most non-syncytium-inducing isolates could utilize only CCR5, but a longitudinal series of HIV-1 subtype B isolates from an infected infant and its mother utilized Bonzo efficiently.
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Persistent HIV-1 infection of natural killer cells in patients receiving highly active antiretroviral therapy
Antonio Valentin,Margherita Rosati,Daniel J. Patenaude,Angelos Hatzakis,Leondios G. Kostrikis,Marios Lazanas,Kathleen M. Wyvill,Robert Yarchoan,George N. Pavlakis +8 more
TL;DR: It is demonstrated that a subset of non-T cells with NK markers are persistently infected and suggest that HIV infection of NK cells is important for virus persistence, and the properties of the virus reservoir in these cells should be considered in attempts to further optimize antiretroviral therapies.
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A Polymorphism in the Regulatory Region of the CC-Chemokine Receptor 5 Gene Influences Perinatal Transmission of Human Immunodeficiency Virus Type 1 to African-American Infants
Leondios G. Kostrikis,Avidan U. Neumann,Bruce Thomson,Bette T. Korber,Paul McHardy,Rose Karanicolas,Lisa Deutsch,Yaoxing Huang,Judy F. Lew,Kenneth McIntosh,Henry Pollack,William Borkowsky,Hans M. L. Spiegel,Paul Palumbo,James M. Oleske,Arlene Bardeguez,Katherine Luzuriaga,John L. Sullivan,Steven M. Wolinsky,Richard A. Koup,David D. Ho,John P. Moore +21 more
TL;DR: Homozygosity for CCR5-59356-T is strongly associated with an increased rate of perinatal HIV-1 transmission, and this mutation varies between population groups in the United States, a low frequency occurring in Caucasians and a higher frequency occurs in African-Americans.