L
Leopold Sellner
Researcher at Takeda Pharmaceutical Company
Publications - 60
Citations - 1734
Leopold Sellner is an academic researcher from Takeda Pharmaceutical Company. The author has contributed to research in topics: Chronic lymphocytic leukemia & T cell. The author has an hindex of 21, co-authored 58 publications receiving 1256 citations. Previous affiliations of Leopold Sellner include University Hospital Heidelberg & Heidelberg University.
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Journal ArticleDOI
p53-dependent non-coding RNA networks in chronic lymphocytic leukemia.
Carolin Blume,Agnes Hotz-Wagenblatt,Jennifer Hüllein,Leopold Sellner,Leopold Sellner,Alexander Jethwa,Tatjana Stolz,Mikolaj Slabicki,Kwang Seok Lee,Arandkar Sharathchandra,Axel Benner,Sascha Dietrich,Sascha Dietrich,Christopher C. Oakes,Peter Dreger,D. te Raa,Arnon P. Kater,Anna Jauch,Olaf Merkel,Olaf Merkel,Moshe Oren,Thomas Hielscher,Thorsten Zenz,Thorsten Zenz +23 more
TL;DR: The p53-dependent miRNome is described and lncRNAs NEAT1 and lincRNA-p21 are identified as novel elements of the p 53-dependent DNA damage response machinery in CLL and lymphoma.
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Lysosome-Targeting Amplifiers of Reactive Oxygen Species as Anticancer Prodrugs.
Steffen Daum,M. S. Viktor Reshetnikov,Miroslav Sisa,Tetyana Dumych,Maxim D. Lootsik,Rostyslav Bilyy,Evgenia Bila,Christina Janko,Christoph Alexiou,Martin Herrmann,Leopold Sellner,Andriy Mokhir +11 more
TL;DR: This work proposes and validate a potentially general approach for solving the intrinsic problem of ROS-dependent prodrugs and finds it to exhibit high anticancer activity in a variety of cancer cell lines and in vivo.
Journal ArticleDOI
Drug-perturbation-based stratification of blood cancer
Sascha Dietrich,Małgorzata Oleś,Junyan Lu,Leopold Sellner,Simon Anders,Britta Velten,Bian Wu,Jennifer Hüllein,Michelle da Silva Liberio,Tatjana Walther,Lena Wagner,Sophie Rabe,Sophie Rabe,Sonja Ghidelli-Disse,Marcus Bantscheff,Andrzej K. Oleś,Mikolaj Slabicki,Andreas Mock,Christopher C. Oakes,Christopher C. Oakes,Shihui Wang,Sina Oppermann,Marina Lukas,Vladislav Kim,Martin Sill,Axel Benner,Anna Jauch,Lesley-Ann Sutton,Emma Young,Richard Rosenquist,Xiyang Liu,Alexander Jethwa,Kwang Seok Lee,Joe Lewis,Kerstin Putzker,Christoph Lutz,Davide Rossi,Andriy Mokhir,Thomas Oellerich,Thomas Oellerich,Katja Zirlik,Marco Herling,Florence Nguyen-Khac,Christoph Plass,Christoph Plass,Emma I. Andersson,Satu Mustjoki,Christof von Kalle,Anthony D. Ho,Manfred Hensel,Jan Dürig,Ingo Ringshausen,Marc Zapatka,Wolfgang Huber,Wolfgang Huber,Thorsten Zenz +55 more
TL;DR: This study overcomes the perception that most mutations do not influence drug response of cancer, and points to an updated approach to understanding tumor biology, with implications for biomarker discovery and cancer care.
Journal ArticleDOI
Aminoferrocene-Based Prodrugs and Their Effects on Human Normal and Cancer Cells as Well as Bacterial Cells
Paul Marzenell,Helen Hagen,Leopold Sellner,Thorsten Zenz,Ruta Grinyte,Valeri Pavlov,Steffen Daum,Andriy Mokhir +7 more
TL;DR: It is demonstrated that the prodrugs are active against primary chronic lymphocytic leukemia (CLL) cells, with the best compounds exhibiting an IC50 value of 1.5 μM, and the most active compounds were found to not affect mononuclear cells and representative bacterial cells.
Journal ArticleDOI
ARResT/Interrogate: an interactive immunoprofiler for IG/TR NGS data.
Vojtech Bystry,Tomáš Reigl,Adam Krejci,Martin Demko,Barbora Hanakova,Andrea Grioni,Andrea Grioni,Henrik Knecht,Max Schlitt,Peter Dreger,Leopold Sellner,Dietrich Herrmann,Marine Pingeon,Myriam Boudjoghra,Jos Rijntjes,Christiane Pott,Anton W. Langerak,Patricia J. T. A. Groenen,Frederic Davi,Monika Brüggemann,Nikos Darzentas +20 more
TL;DR: ARResT/Interrogate, a web‐based, interactive application that can organize and filter large amounts of immunogenetic data by numerous criteria, calculate several relevant statistics, and present results in the form of multiple interconnected visualizations is implemented.