L
Leylah Drusbosky
Researcher at University of Florida
Publications - 70
Citations - 1138
Leylah Drusbosky is an academic researcher from University of Florida. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 9, co-authored 34 publications receiving 607 citations. Previous affiliations of Leylah Drusbosky include Archer.
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Journal ArticleDOI
Functional genomic landscape of acute myeloid leukaemia
Jeffrey W. Tyner,Cristina E. Tognon,Cristina E. Tognon,Daniel Bottomly,Beth Wilmot,Stephen E. Kurtz,Samantha L. Savage,Nicola Long,Anna Reister Schultz,Elie Traer,Melissa L. Abel,Anupriya Agarwal,Aurora Blucher,Uma Borate,Jade Bryant,Russell T. Burke,Amy S. Carlos,Richie Carpenter,Joseph Carroll,Bill H. Chang,Cody Coblentz,Amanda d’Almeida,Rachel J. Cook,Alexey V. Danilov,Kim Hien T. Dao,Michie Degnin,Deirdre Devine,James Dibb,David K. Edwards,Christopher A. Eide,Christopher A. Eide,Isabel English,Jason M. Glover,Rachel Henson,Hibery Ho,Abdusebur Jemal,Kara Johnson,Ryan C. Johnson,Brian Junio,Andy Kaempf,Jessica Leonard,Chenwei Lin,Selina Qiuying Liu,Pierrette Lo,Marc M. Loriaux,Samuel B. Luty,Tara A. Macey,Jason D. MacManiman,Jacqueline Martinez,Motomi Mori,Dylan Nelson,Ceilidh Nichols,Jill Peters,Justin Ramsdill,Angela Rofelty,Robert Schuff,Robert P. Searles,Erik Segerdell,Rebecca Smith,Stephen E. Spurgeon,Tyler Sweeney,Aashis Thapa,Corinne Visser,Jake Wagner,Kevin Watanabe-Smith,Kristen Werth,Joelle Wolf,Libbey White,Amy Yates,Haijiao Zhang,Christopher R. Cogle,Robert H. Collins,Denise C. Connolly,Michael W. Deininger,Leylah Drusbosky,Christopher S. Hourigan,Craig T. Jordan,Patricia Kropf,Tara L. Lin,Micaela E. Martinez,Bruno C. Medeiros,Rachel R. Pallapati,Daniel A. Pollyea,Ronan T. Swords,Justin M. Watts,Scott Weir,David L. Wiest,Ryan M. Winters,Shannon K. McWeeney,Brian J. Druker,Brian J. Druker +90 more
TL;DR: Analyses of samples from patients with acute myeloid leukaemia reveal that drug response is associated with mutational status and gene expression; the generated dataset provides a basis for future clinical and functional studies of this disease.
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CTCF boundary remodels chromatin domain and drives aberrant HOX gene transcription in acute myeloid leukemia
Huacheng Luo,Fei Wang,Fei Wang,Jie Zha,Jie Zha,Haoli Li,Haoli Li,Bowen Yan,Qinghua Du,Feng Chun Yang,Amin Sobh,Chris D. Vulpe,Leylah Drusbosky,Christopher R. Cogle,Iouri Chepelev,Bing Xu,Stephen D. Nimer,Jonathan D. Licht,Yi Qiu,Baoan Chen,Mingjiang Xu,Suming Huang,Suming Huang +22 more
TL;DR: The CTCF boundary constrains the normal gene-expression program, as well as plays a role in maintaining the oncogenic transcription program for leukemic transformation, which may serve as novel therapeutic targets for the treatment of myeloid malignancies.
Journal ArticleDOI
Ex-vivo sensitivity profiling to guide clinical decision making in acute myeloid leukemia: A pilot study
Ronan T. Swords,Diana J. Azzam,Hassan Al-Ali,Ines Lohse,Claude-Henry Volmar,Justin M. Watts,Aymee Perez,Ana Rodriguez,Fernando Vargas,Roy Elias,Francisco Vega,Arthur Zelent,Taher Abbasi,Jonathan C. Trent,Shaukat Rangwala,Yehuda E. Deutsch,Eibhlin Conneally,Leylah Drusbosky,Christopher R. Cogle,Claes Wahlestedt +19 more
TL;DR: DST rapidly and effectively provides personalized treatment recommendations for patients with refractory AML, and survival benefit of DST-guided therapy as compared to the survival of patients treated according to physician recommendation is observed.
Journal ArticleDOI
Therapeutic strategies in RET gene rearranged non-small cell lung cancer
TL;DR: Recently, the results from the LIBRETTO-001 and ARROW clinical trials demonstrated significant clinical benefits with selpercatinib and pralsetinib respectively, in NSCLC patients with RET gene fusions, with tolerable toxicity profiles.
Journal ArticleDOI
Interleukin-8 blockade prevents activated endothelial cell mediated proliferation and chemoresistance of acute myeloid leukemia.
Vindhya Vijay,Regan Miller,Gau Shoua Vue,Mida Bahareh Pezeshkian,Michael Maywood,Allison M. Ast,Leylah Drusbosky,Yuri A. Pompeu,Alan D. Salgado,Samuel D. Lipten,Timothy J. Geddes,Ann Marie Blenc,Yubin Ge,David A. Ostrov,Christopher R. Cogle,Gerard J. Madlambayan +15 more
TL;DR: It is shown mechanistically that EC activation induces the secretion of interleukin-8 (IL-8) leading to significant expansion of non-adherent AML cells and resistance to cytarabine (Ara-C).