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Chenwei Lin
Researcher at Oregon Health & Science University
Publications - 4
Citations - 955
Chenwei Lin is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Exome sequencing & Atypical chronic myeloid leukemia. The author has an hindex of 3, co-authored 3 publications receiving 487 citations.
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Journal ArticleDOI
Functional genomic landscape of acute myeloid leukaemia
Jeffrey W. Tyner,Cristina E. Tognon,Cristina E. Tognon,Daniel Bottomly,Beth Wilmot,Stephen E. Kurtz,Samantha L. Savage,Nicola Long,Anna Reister Schultz,Elie Traer,Melissa L. Abel,Anupriya Agarwal,Aurora Blucher,Uma Borate,Jade Bryant,Russell T. Burke,Amy S. Carlos,Richie Carpenter,Joseph Carroll,Bill H. Chang,Cody Coblentz,Amanda d’Almeida,Rachel J. Cook,Alexey V. Danilov,Kim Hien T. Dao,Michie Degnin,Deirdre Devine,James Dibb,David K. Edwards,Christopher A. Eide,Christopher A. Eide,Isabel English,Jason M. Glover,Rachel Henson,Hibery Ho,Abdusebur Jemal,Kara Johnson,Ryan C. Johnson,Brian Junio,Andy Kaempf,Jessica Leonard,Chenwei Lin,Selina Qiuying Liu,Pierrette Lo,Marc M. Loriaux,Samuel B. Luty,Tara A. Macey,Jason D. MacManiman,Jacqueline Martinez,Motomi Mori,Dylan Nelson,Ceilidh Nichols,Jill Peters,Justin Ramsdill,Angela Rofelty,Robert Schuff,Robert P. Searles,Erik Segerdell,Rebecca Smith,Stephen E. Spurgeon,Tyler Sweeney,Aashis Thapa,Corinne Visser,Jake Wagner,Kevin Watanabe-Smith,Kristen Werth,Joelle Wolf,Libbey White,Amy Yates,Haijiao Zhang,Christopher R. Cogle,Robert H. Collins,Denise C. Connolly,Michael W. Deininger,Leylah Drusbosky,Christopher S. Hourigan,Craig T. Jordan,Patricia Kropf,Tara L. Lin,Micaela E. Martinez,Bruno C. Medeiros,Rachel R. Pallapati,Daniel A. Pollyea,Ronan T. Swords,Justin M. Watts,Scott Weir,David L. Wiest,Ryan M. Winters,Shannon K. McWeeney,Brian J. Druker,Brian J. Druker +90 more
TL;DR: Analyses of samples from patients with acute myeloid leukaemia reveal that drug response is associated with mutational status and gene expression; the generated dataset provides a basis for future clinical and functional studies of this disease.
Journal ArticleDOI
Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms
Haijiao Zhang,Samantha L. Savage,Anna Reister Schultz,Daniel Bottomly,Libbey White,Erik Segerdell,Beth Wilmot,Shannon K. McWeeney,Christopher A. Eide,Christopher A. Eide,Tamilla Nechiporuk,Amy S. Carlos,Rachel Henson,Chenwei Lin,Robert P. Searles,Hoang Ho,Yee Ling Lam,Richard S. Sweat,Courtney Follit,Vinay K. Jain,Evan F. Lind,Gautam Borthakur,Guillermo Garcia-Manero,Farhad Ravandi,Hagop M. Kantarjian,Jorge E. Cortes,Robert H. Collins,Daelynn R. Buelow,Sharyn D. Baker,Brian J. Druker,Brian J. Druker,Jeffrey W. Tyner +31 more
TL;DR: Exome sequencing of samples from patients treated with the FLT3 inhibitor, crenolanib, is performed to show that resistance occurs due to diverse molecular mechanisms, not primarily due to secondaryFLT3 mutations.
Journal ArticleDOI
Genomic landscape of neutrophilic leukemias of ambiguous diagnosis
Haijiao Zhang,Beth Wilmot,Daniel Bottomly,Kim Hien T. Dao,Emily A. Stevens,Christopher A. Eide,Vishesh Khanna,Angela Rofelty,Samantha L. Savage,Anna Reister Schultz,Nicola Long,Libbey White,Amy S. Carlos,Rachel Henson,Chenwei Lin,Robert P. Searles,Robert H. Collins,Daniel J. DeAngelo,Michael W. Deininger,Tamara J. Dunn,Than Hein,Marlise R. Luskin,Bruno C. Medeiros,Stephen T. Oh,Daniel A. Pollyea,David P. Steensma,Richard Stone,Brian J. Druker,Shannon K. McWeeney,Julia E. Maxson,Jason Gotlib,Jeffrey W. Tyner +31 more
TL;DR: This work performed whole exome and RNA-sequencing of these rare hematologic malignancies and present the most complete survey of the genomic landscape of these diseases to date, finding a diversity of combinatorial mutational patterns that generally do not cluster within any one diagnosis.
Journal ArticleDOI
Integrative analysis of drug response and clinical outcome in acute myeloid leukemia.
Daniel Bottomly,Nicola Long,Anna Reister Schultz,Stephen E. Kurtz,Cristina E. Tognon,Kara Johnson,Melissa L. Abel,Anupriya Agarwal,Sammantha Avaylon,Erik Benton,Aurora Blucher,Uma Borate,Theodore P. Braun,Jordana Brown,Jade Bryant,Russell T. Burke,Amy S. Carlos,Bill H. Chang,Hyun Jun Cho,Stephen Fuller Christy,Cody Coblentz,Aaron Cohen,Amanda d’Almeida,Rachel E. Cook,Alexey V. Danilov,Kim Hien T. Dao,Michie Degnin,James Dibb,Christopher A. Eide,Isabel English,Stuart Hagler,Heather Harrelson,Rachel Henson,Hibery Ho,Sunil K. Joshi,Brian Junio,Andy Kaempf,Yoko Kosaka,Ted Laderas,M.R. Lawhead,Hyunjung Lee,Jessica Leonard,Chenwei Lin,Evan F. Lind,Selina Qiuying Liu,Pierrette Lo,Marc M. Loriaux,Samuel B. Luty,Julia E. Maxson,Tara A. Macey,Jacqueline Martinez,Jessica Minnier,Andrea Monteblanco,M. Morii,Quin Morrow,Dylan Nelson,Justin Ramsdill,Angela Rofelty,Alexandria Rogers,Kyle A. Romine,Peter Ryabinin,Jennifer N. Saultz,David A. Sampson,Samantha L. Savage,Robert Schuff,Robert A. Searles,Rebecca L. Smith,Stephen E. Spurgeon,Tyler Sweeney,Ronan T. Swords,Aashis Thapa,Karina Thiel-Klare,Elie Traer,Jake Wagner,Beth Wilmot,Joelle Wolf,Guanming Wu,Amy M. Yates,Haijiao Zhang,Christopher R. Cogle,P. Collins,Michael W. Deininger,Christopher S. Hourigan,Craig T. Jordan,Tara L. Lin,Micaela E. Martinez,Rachel R. Pallapati,Daniel A. Pollyea,Anthony D. Pomicter,Justin M. Watts,Scott Weir,Brian J. Druker,Shannon K. McWeeney,Jeffrey W. Tyner +93 more
TL;DR: A large functional genomic resource is expanded, avenues for mechanistic exploration and drug development, and tools for predicting outcome in AML are revealed, including a single gene, PEAR1, which is found to be among the strongest predictors of patient survival.