L
Li-Juan Wang
Researcher at Laboratory of Molecular Biology
Publications - 4
Citations - 839
Li-Juan Wang is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Ezetimibe & Interleukin 21. The author has an hindex of 4, co-authored 4 publications receiving 588 citations.
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Journal ArticleDOI
Potentiating the antitumour response of CD8 + T cells by modulating cholesterol metabolism
Wei Yang,Bai Yibing,Ying Xiong,Jin Zhang,S.H. Chen,Xiaojun Zheng,Xiangbo Meng,L. Li,Jing Wang,Chenguang Xu,Chengsong Yan,Li-Juan Wang,Catharine C.Y. Chang,Ta-Yuan Chang,Ti Zhang,Penghui Zhou,Bao-Liang Song,Wanli Liu,Shao Cong Sun,Xiaolong Liu,Bo-Liang Li,Chenqi Xu,Chenqi Xu +22 more
TL;DR: A new mechanism by which the antitumour response of mouse CD8+ T cells can be potentiated by modulating cholesterol metabolism is reported, which indicates ACAT1, an established target for atherosclerosis, is therefore also a potential target for cancer immunotherapy.
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Flotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake.
TL;DR: A functional role of flotillins in NPC1L1-mediated cholesterol uptake is revealed and the formation of NPC1 L1–flotillin-postive cholesterol-enriched membrane microdomains as a mechanism for efficient cholesterol absorption is elucidated.
Journal ArticleDOI
Niemann-Pick C1-Like 1 and cholesterol uptake.
Li-Juan Wang,Bao-Liang Song +1 more
TL;DR: A working model of NPC1L1's role in cholesterol uptake and metabolism is proposed and proposed, hoping to provide new perspectives on the regulation of cholesterol transport and metabolism.
Journal ArticleDOI
Molecular characterization of the NPC1L1 variants identified from cholesterol low absorbers.
TL;DR: It is suggested that the dysfunction of the 19 reported NS variants on cholesterol absorption is due to the impairment of recycling, subcellular localization, glycosylation, or stability of NPC1L1.