L
L. Li
Researcher at Chinese Academy of Sciences
Publications - 31
Citations - 1326
L. Li is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Laser & Quantum cascade laser. The author has an hindex of 12, co-authored 31 publications receiving 987 citations. Previous affiliations of L. Li include University of Science and Technology of China & Laboratory of Molecular Biology.
Papers
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Journal ArticleDOI
Potentiating the antitumour response of CD8 + T cells by modulating cholesterol metabolism
Wei Yang,Bai Yibing,Ying Xiong,Jin Zhang,S.H. Chen,Xiaojun Zheng,Xiangbo Meng,L. Li,Jing Wang,Chenguang Xu,Chengsong Yan,Li-Juan Wang,Catharine C.Y. Chang,Ta-Yuan Chang,Ti Zhang,Penghui Zhou,Bao-Liang Song,Wanli Liu,Shao Cong Sun,Xiaolong Liu,Bo-Liang Li,Chenqi Xu,Chenqi Xu +22 more
TL;DR: A new mechanism by which the antitumour response of mouse CD8+ T cells can be potentiated by modulating cholesterol metabolism is reported, which indicates ACAT1, an established target for atherosclerosis, is therefore also a potential target for cancer immunotherapy.
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Ca2+ regulates T-cell receptor activation by modulating the charge property of lipids
Xiaoshan Shi,Yunchen Bi,Wei Yang,Wei Yang,Xingdong Guo,Xingdong Guo,Yan Jiang,Yan Jiang,Chanjuan Wan,L. Li,L. Li,Bai Yibing,Bai Yibing,Jun Guo,Jun Guo,Yujuan Wang,Xiang-Jun Chen,Bo Wu,Hongbin Sun,Wanli Liu,Junfeng Wang,Chenqi Xu,Chenqi Xu +22 more
TL;DR: This study provides a new regulatory mechanism of Ca2+ to T-cell activation involving direct lipid manipulation that has a positive feedback effect on amplifying and sustaining CD3 phosphorylation and should enhance T- cell sensitivity to foreign antigens.
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Regulation of EGFR nanocluster formation by ionic protein-lipid interaction
Ye Wang,Jing Gao,Xingdong Guo,Ti Tong,Xiaoshan Shi,L. Li,Miao Qi,Yajie Wang,Mingjun Cai,Junguang Jiang,Chenqi Xu,Hongbin Ji,Hongda Wang +12 more
TL;DR: dSTORM findings highlight the key roles of anionic phospholipids in EGFR signaling and function, and reveal a novel mechanism to explain the aberrant activation of EGFR in cancers.
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Ionic protein–lipid interaction at the plasma membrane: what can the charge do?
TL;DR: How acidic phospholipids in the plasma membrane regulate protein structure and function via ionic interactions, and how Ca(2+) regulates ionic protein-lipid interactions via direct and indirect mechanisms are reviewed.
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A Scanning Electron Microscopy Study on the Morphologies of Isotactic Polypropylene Induced by Its Own Fibers
TL;DR: In this paper, the morphologies of iPP fiber/matrix homogeneity composites were studied on a lamellar level with the help of a field emission scanning electron microscope.