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Wei Yang
Researcher at Southern Medical University
Publications - 29
Citations - 2246
Wei Yang is an academic researcher from Southern Medical University. The author has contributed to research in topics: Cancer & CD8. The author has an hindex of 12, co-authored 24 publications receiving 1474 citations. Previous affiliations of Wei Yang include Chinese Academy of Sciences & Laboratory of Molecular Biology.
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Journal ArticleDOI
Potentiating the antitumour response of CD8 + T cells by modulating cholesterol metabolism
Wei Yang,Bai Yibing,Ying Xiong,Jin Zhang,S.H. Chen,Xiaojun Zheng,Xiangbo Meng,L. Li,Jing Wang,Chenguang Xu,Chengsong Yan,Li-Juan Wang,Catharine C.Y. Chang,Ta-Yuan Chang,Ti Zhang,Penghui Zhou,Bao-Liang Song,Wanli Liu,Shao Cong Sun,Xiaolong Liu,Bo-Liang Li,Chenqi Xu,Chenqi Xu +22 more
TL;DR: A new mechanism by which the antitumour response of mouse CD8+ T cells can be potentiated by modulating cholesterol metabolism is reported, which indicates ACAT1, an established target for atherosclerosis, is therefore also a potential target for cancer immunotherapy.
Journal ArticleDOI
Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis.
Zhicheng Zeng,Yuling Li,Yangjian Pan,Xiaoliang Lan,Fuyao Song,Jingbo Sun,Kun Zhou,Xiaolong Liu,Xiaoli Ren,Feifei Wang,Jinlong Hu,Xiaohui Zhu,Wei Yang,Wenting Liao,Guoxin Li,Yanqing Ding,Li Liang +16 more
TL;DR: It is shown that colorectal cancer (CRC) derived exosomal miR-25-3p promotes vascular leakiness and angiogenesis, CRC metastasis, and is upregulated in CRC pateints with metastasis.
Journal ArticleDOI
Structure and mechanism of human DNA polymerase η
Christian Biertümpfel,Ye Zhao,Ye Zhao,Yuji Kondo,Santiago Ramón-Maiques,Santiago Ramón-Maiques,Mark S. Gregory,Jae Young Lee,Jae Young Lee,Chikahide Masutani,Alan R. Lehmann,Fumio Hanaoka,Fumio Hanaoka,Wei Yang +13 more
TL;DR: High-resolution crystal structures of human Polη at four consecutive steps during DNA synthesis through cis-syn cyclobutane thymine thymine dimers provide an insight into the role of Pol η in replicating through D loop and DNA fragile sites.
Journal ArticleDOI
Ca2+ regulates T-cell receptor activation by modulating the charge property of lipids
Xiaoshan Shi,Yunchen Bi,Wei Yang,Wei Yang,Xingdong Guo,Xingdong Guo,Yan Jiang,Yan Jiang,Chanjuan Wan,L. Li,L. Li,Bai Yibing,Bai Yibing,Jun Guo,Jun Guo,Yujuan Wang,Xiang-Jun Chen,Bo Wu,Hongbin Sun,Wanli Liu,Junfeng Wang,Chenqi Xu,Chenqi Xu +22 more
TL;DR: This study provides a new regulatory mechanism of Ca2+ to T-cell activation involving direct lipid manipulation that has a positive feedback effect on amplifying and sustaining CD3 phosphorylation and should enhance T- cell sensitivity to foreign antigens.
Journal ArticleDOI
FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells
Xiangbo Meng,Xiwei Liu,Xingdong Guo,Shutan Jiang,Tingting Chen,Zhiqiang Hu,Haifeng Liu,Bai Yibing,Manman Xue,Ronggui Hu,Shao Cong Sun,Xiaolong Liu,Penghui Zhou,Xiaowu Huang,Lai Wei,Wei Yang,Chenqi Xu,Chenqi Xu +17 more
TL;DR: It is shown that surface PD-1 undergoes internalization, subsequent ubiquitination and proteasome degradation in activated T cells, and inhibition of this pathway dampens anti-tumour immunity of T cells.