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Chenqi Xu
Researcher at Chinese Academy of Sciences
Publications - 82
Citations - 4290
Chenqi Xu is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: T-cell receptor & Medicine. The author has an hindex of 27, co-authored 65 publications receiving 2848 citations. Previous affiliations of Chenqi Xu include Laboratory of Molecular Biology & Katholieke Universiteit Leuven.
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Journal ArticleDOI
Potentiating the antitumour response of CD8 + T cells by modulating cholesterol metabolism
Wei Yang,Bai Yibing,Ying Xiong,Jin Zhang,S.H. Chen,Xiaojun Zheng,Xiangbo Meng,L. Li,Jing Wang,Chenguang Xu,Chengsong Yan,Li-Juan Wang,Catharine C.Y. Chang,Ta-Yuan Chang,Ti Zhang,Penghui Zhou,Bao-Liang Song,Wanli Liu,Shao Cong Sun,Xiaolong Liu,Bo-Liang Li,Chenqi Xu,Chenqi Xu +22 more
TL;DR: A new mechanism by which the antitumour response of mouse CD8+ T cells can be potentiated by modulating cholesterol metabolism is reported, which indicates ACAT1, an established target for atherosclerosis, is therefore also a potential target for cancer immunotherapy.
Journal ArticleDOI
Immune checkpoint signaling and cancer immunotherapy.
Xing He,Chenqi Xu,Chenqi Xu +2 more
TL;DR: Regulation of immune checkpoint signaling at multiple levels is discussed to provide an overview of the current understanding of checkpoint biology and includes the regulation of surface expression levels for known immune checkpoint proteins via surface delivery, internalization, recycling, and degradation.
Journal ArticleDOI
Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based Motif
Chenqi Xu,Etienne Gagnon,Matthew E. Call,Jason R. Schnell,Charles D. Schwieters,Christopher V. Carman,James J. Chou,Kai W. Wucherpfennig +7 more
TL;DR: Receptor ligation needs to result in unbinding of the CD3epsilon ITAM from the membrane to render these tyrosines accessible to Src kinases and represents a previously unrecognized mechanism for control of receptor activation.
Journal ArticleDOI
Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein
Kevin C. O’Connor,Katherine McLaughlin,Philip L. De Jager,Tanuja Chitnis,Tanuja Chitnis,Estelle Bettelli,Estelle Bettelli,Chenqi Xu,William H. Robinson,Sunil V. Cherry,Sunil V. Cherry,Amit Bar-Or,Brenda Banwell,Hikoaki Fukaura,Toshiyuki Fukazawa,Silvia Tenembaum,Susan J. Wong,Norma P. Tavakoli,Zhannat Idrissova,Vissia Viglietta,Vissia Viglietta,Kevin Rostasy,Daniela Pohl,Russell C. Dale,Mark S. Freedman,Lawrence Steinman,Guy J. Buckle,Guy J. Buckle,Vijay K. Kuchroo,Vijay K. Kuchroo,David A. Hafler,Kai W. Wucherpfennig +31 more
TL;DR: A sensitive assay based on self-assembling radiolabeled tetramers that allows discrimination of antibodies against folded or denatured myelin oligodendrocyte glycoprotein (MOG) by selective unfolding of the antigen domain is developed.
Journal ArticleDOI
Cholesterol metabolism in cancer: mechanisms and therapeutic opportunities
TL;DR: A comprehensive overview of cholesterol metabolism in cancer cells and its effects on immune cells of the tumour microenvironment is provided, highlighting its effect on cancer growth as well as opportunities for therapeutic intervention.