Lilei Zhang

TL;DR: This work establishes KLF15 as a key regulator of myocardial lipid utilization and is the first to implicate the KLF transcription factor family in cardiac metabolism, a core component of the transcriptional circuitry that governs cardiac metabolism.

TL;DR: This study provides the genetic and functional evidence that mutant iGluR3 with altered kinetic properties is associated with moderate cognitive impairment in humans.

TL;DR: It is shown that the transcription factor Kruppel-like factor 4 (KLF4) governs mitochondrial biogenesis, metabolic function, dynamics, and autophagic clearance, and it is determined that KLF4 binds to, cooperates with, and is requisite for optimal function of the estrogen-related receptor/PPARγ coactivator 1 transcriptional regulatory module on metabolic and mitochondrial targets.

TL;DR: In this paper, the authors identify a KLF15-Fgf15 signalling axis that regulates BA production in the liver and find that it is a potent inhibitor of BA synthesis.

TL;DR: It is shown that kruppel-like factor 15 (KLF15) governs a biphasic transcriptomic oscillation in the heart with a maximum ATP production phase and a remodeling and repair phase corresponding to the active and resting phase of a rodent.