L
Lin Cheng
Researcher at Southern University of Science and Technology
Publications - 34
Citations - 2379
Lin Cheng is an academic researcher from Southern University of Science and Technology. The author has contributed to research in topics: Medicine & Antibody. The author has an hindex of 6, co-authored 14 publications receiving 1165 citations.
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Journal ArticleDOI
Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19.
Mingfeng Liao,Yang Liu,Jing Yuan,Yanling Wen,Gang Xu,Juanjuan Zhao,Lin Cheng,Jinxiu Li,Xin Wang,Fuxiang Wang,Lei Liu,Ido Amit,Shuye Zhang,Zheng Zhang +13 more
TL;DR: Single-cell transcriptome and T cell receptor analysis of bronchoalveolar lavage fluid suggests enrichment of proinflammatory macrophages in patients with severe COVID-19 and the presence of clonally expanded CD8 + T cells in Patients with moderate CO VID-19.
Journal ArticleDOI
Antibody neutralization of SARS-CoV-2 through ACE2 receptor mimicry.
Jiwan Ge,Ruoke Wang,Bin Ju,Qi Zhang,Jing Sun,Peng Chen,Senyan Zhang,Yuling Tian,Sisi Shan,Lin Cheng,Bing Zhou,Shuo Song,Juanjuan Zhao,Haiyan Wang,Xuanling Shi,Qiang Ding,Lei Liu,Jincun Zhao,Zheng Zhang,Xinquan Wang,Linqi Zhang +20 more
TL;DR: In this paper, the top three most potent yet variable neutralizing antibodies for SARS-CoV-2 infection in Ad5-hACE2-sensitized mice were identified.
Journal ArticleDOI
Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2.
Qi Zhang,Bin Ju,Jiwan Ge,Jasper Fuk-Woo Chan,Jasper Fuk-Woo Chan,Lin Cheng,Ruoke Wang,Weijin Huang,Mengqi Fang,Peng Chen,Bing Zhou,Shuo Song,Sisi Shan,Baohua Yan,Senyan Zhang,Xiangyang Ge,Jiazhen Yu,Juanjuan Zhao,Haiyan Wang,Li Liu,Qining Lv,Lili Fu,Xuanling Shi,Kwok-Yung Yuen,Kwok-Yung Yuen,Lei Liu,Youchun Wang,Zhiwei Chen,Zhiwei Chen,Linqi Zhang,Xinquan Wang,Zheng Zhang +31 more
TL;DR: In this article, a total of 165 antibodies from eight SARS-CoV-19 patients were examined and found that potent nAbs from different patients have disproportionally high representation of IGHV3-53/3-66 usage, and therefore termed as public antibodies.
Journal ArticleDOI
Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies.
Renhong Yan,Ruoke Wang,Bin Ju,Jinfang Yu,Yuanyuan Zhang,Nan Liu,Jia Wang,Qi Zhang,Peng Chen,Bing Zhou,Yaning Li,Yaping Shen,Shuyuan Zhang,Long Tian,Yingying Guo,Lu Xia,Xinyue Zhong,Lin Cheng,Xiangyang Ge,Juanjuan Zhao,Hong-Wei Wang,Xinquan Wang,Zheng Zhang,Linqi Zhang,Qiang Zhou +24 more
TL;DR: In this paper, the bivalent binding of the full-length IgG is found to associate with more RBDs in the "up" conformation than the monovalent binding of Fab, perhaps contributing to the enhanced neutralizing activity of IgG and triggering more shedding of the S1 subunit from the S protein.
Journal ArticleDOI
Interferon-armed RBD dimer enhances the immunogenicity of RBD for sterilizing immunity against SARS-CoV-2.
Shiyu Sun,Yueqi Cai,Tian-Zhang Song,Yang Pu,Lin Cheng,Hairong Xu,Jing Sun,Chaoyang Meng,Yifan Lin,Haibin Huang,Fang Zhao,Silin Zhang,Yu Gao,Jian-Bao Han,Xiao-Li Feng,Dan-Dan Yu,Yalan Zhu,Pu Gao,Haidong Tang,Jincun Zhao,Zheng Zhang,Jiaming Yang,Zhenxiang Hu,Yang Xin Fu,Yong-Tang Zheng,Hua Peng +25 more
TL;DR: In this article, an interferon-armed RBD dimerized by an immunoglobulin fragment (I-R-F) was developed to enhance antigen processing and cross-presentation in draining lymph nodes (DLNs).