L
Line M. Myklebust
Researcher at University of Bergen
Publications - 22
Citations - 1302
Line M. Myklebust is an academic researcher from University of Bergen. The author has contributed to research in topics: Acetylation & NAA15. The author has an hindex of 13, co-authored 21 publications receiving 1021 citations.
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Journal ArticleDOI
The world of protein acetylation
TL;DR: This review gives a general overview of protein acetylation and the respective acetyltransferases, and focuses on the regulation of metabolic processes and physiological consequences that come along with proteinacetylation.
Journal ArticleDOI
Downregulation of N-terminal acetylation triggers ABA-mediated drought responses in Arabidopsis
Eric Linster,Iwona Stephan,Willy V. Bienvenut,Jodi Maple-Grødem,Line M. Myklebust,Monika Huber,Michael Reichelt,Carsten Sticht,Simon Geir Møller,Thierry Meinnel,Thomas Arnesen,Carmela Giglione,Rüdiger Hell,Markus Wirtz +13 more
TL;DR: It is proposed that NTA by the NatA complex acts as a cellular surveillance mechanism during stress and that imprinting of the proteome by NatA is an important switch for the control of metabolism, development and cellular stress responses downstream of abscisic acid.
Journal ArticleDOI
The MDM2 Promoter SNP285C/309G Haplotype Diminishes Sp1 Transcription Factor Binding and Reduces Risk for Breast and Ovarian Cancer in Caucasians
Stian Knappskog,Stian Knappskog,Merete Bjørnslett,Merete Bjørnslett,Line M. Myklebust,Petra E A Huijts,Maaike P.G. Vreeswijk,Hege Edvardsen,Yongli Guo,Xuemei Zhang,Ming Yang,Sanna K. Ylisaukko-oja,Pia Alhopuro,Johanna Arola,Rob A. E. M. Tollenaar,Christi J. van Asperen,Caroline Seynaeve,Vidar Staalesen,Vidar Staalesen,Ranjan Chrisanthar,Ranjan Chrisanthar,Erik Løkkevik,Helga B. Salvesen,Helga B. Salvesen,D. Gareth Evans,William G. Newman,Dongxin Lin,Lauri A. Aaltonen,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale,Grethe S. Tell,Camilla Stoltenberg,Pål Richard Romundstad,Kristian Hveem,Johan R. Lillehaug,Lars J. Vatten,Peter Devilee,Anne Dørum,Anne Dørum,Per Eystein Lønning,Per Eystein Lønning +40 more
TL;DR: In vitro analyses reveals that SNP309G enhances but SNP285C strongly reduces Sp1 promoter binding, and a second MDM2 promoter polymorphism, SNP285G > C, residing on the SNP 309G allele is reported.
Journal ArticleDOI
Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects
Line M. Myklebust,Petra Van Damme,Svein Isungset Støve,Max Dorfel,Angèle Abboud,Thomas Vikestad Kalvik,Cédric Grauffel,Veronique Jonckheere,Yiyang Wu,Jeffrey Swensen,Hanna Kaasa,Glen Liszczak,Ronen Marmorstein,Nathalie Reuter,Gholson J. Lyon,Gholson J. Lyon,Kris Gevaert,Thomas Arnesen,Thomas Arnesen +18 more
TL;DR: N-Terminal acetylation clearly plays a role in Ogden syndrome, thus revealing the in vivo importance of N-terminalacetylation in human physiology and disease.
Journal ArticleDOI
De novo missense mutations in the NAA10 gene cause severe non-syndromic developmental delay in males and females
Bernt Popp,Svein Isungset Støve,Sabine Endele,Line M. Myklebust,Juliane Hoyer,Heinrich Sticht,Silvia Azzarello-Burri,Anita Rauch,Thomas Arnesen,André Reis +9 more
TL;DR: In this paper, de novo missense variants in NAA10 were identified in two unrelated individuals, a boy and a girl, with severe global developmental delay but without any major dysmorphism by whole-exome sequencing.