L
Ling Sun
Researcher at University of North Carolina at Chapel Hill
Publications - 5
Citations - 1298
Ling Sun is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Mucin & Cystic fibrosis. The author has an hindex of 3, co-authored 4 publications receiving 733 citations. Previous affiliations of Ling Sun include Sichuan University.
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Journal ArticleDOI
SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract.
Yixuan J. Hou,Kenichi Okuda,Caitlin E. Edwards,David R. Martinez,Takanori Asakura,Kenneth H. Dinnon,Takafumi Kato,Rhianna E. Lee,Boyd Yount,Teresa M. Mascenik,Gang Chen,Kenneth N. Olivier,Andrew J. Ghio,Longping V. Tse,Sarah R. Leist,Lisa E. Gralinski,Alexandra Schäfer,Hong Dang,Rodney C. Gilmore,Satoko Nakano,Ling Sun,M. Leslie Fulcher,Alessandra Livraghi-Butrico,Nathan I. Nicely,Mark J. Cameron,Cheryl M. Cameron,David J. Kelvin,David J. Kelvin,Aravinda M. de Silva,David M. Margolis,Alena J. Markmann,Luther A. Bartelt,Ross E. Zumwalt,Fernando J. Martinez,Steven P. Salvatore,Alain C. Borczuk,Purushothama Rao Tata,Vishwaraj Sontake,Adam J. Kimple,Ilona Jaspers,Wanda K. O'Neal,Scott H. Randell,Richard C. Boucher,Ralph S. Baric +43 more
TL;DR: The nasal susceptibility to SARS-CoV-2 with likely subsequent aspiration-mediated virus seeding to the lung in SARS/COVID-19 pathogenesis is highlighted and reagents provide a foundation for investigations into virus-host interactions in protective immunity, host susceptibility, and virus pathogenesis.
Journal ArticleDOI
IL-1β dominates the promucin secretory cytokine profile in cystic fibrosis
Gang Chen,Ling Sun,Ling Sun,Takafumi Kato,Kenichi Okuda,Mary E. B. Martino,Aiman Abzhanova,Jennifer M. Lin,Rodney C. Gilmore,Bethany D. Batson,Yvonne K. O’Neal,Allison S. Volmer,Hong Dang,Yangmei Deng,Scott H. Randell,Brian Button,Alessandra Livraghi-Butrico,Mehmet Kesimer,Carla Ribeiro,Wanda K. O'Neal,Richard C. Boucher +20 more
TL;DR: IL-1α and IL-1β are upstream components of a signaling pathway that generate a positive feedback cycle capable of producing persistent mucus hyperconcentration and IL, 1α and/or IL,1β-mediated neutrophilic inflammation in the absence of infection in CF airways.
Journal ArticleDOI
XBP1S Regulates MUC5B in a Promoter Variant-Dependent Pathway in Idiopathic Pulmonary Fibrosis Airway Epithelia.
Gang Chen,Carla Ribeiro,Ling Sun,Ling Sun,Kenichi Okuda,Takafumi Kato,Rodney C. Gilmore,Mary E. B. Martino,Hong Dang,Aiman Abzhanova,Jennifer M. Lin,Emily A. Hull-Ryde,Allison S. Volmer,Scott H. Randell,Alessandra Livraghi-Butrico,Yingfeng Deng,Philipp E. Scherer,Barry R. Stripp,Wanda K. O'Neal,Richard C. Boucher +19 more
TL;DR: In this article, a positive feedback bistable ERN2-XBP1S pathway was found to regulate MUC5B-dominated mucus obstruction in IPF, providing an unfolded protein response-dependent mechanism linking the Muc5B promoter rs35705950 polymorphism with IPF pathogenesis.
Journal ArticleDOI
Reuse of Cell Culture Inserts for In Vitro Human Primary Airway Epithelial Cell Studies
Takafumi Kato,Yu Mikami,Ling Sun,Troy D. Rogers,Barbara R. Grubb,Cameron B. Morrison,Camille Ehre,Patrick R. Sears,Lawrence E. Ostrowski,Scott H. Randell,Richard C. Boucher +10 more
Journal ArticleDOI
Chronic airway epithelial hypoxia exacerbates injury in muco-obstructive lung disease through mucus hyperconcentration
Yu Mikami,Barbara R. Grubb,Troy D. Rogers,Hong Dang,Takanori Asakura,Pradeep Kota,Rodney C. Gilmore,Kenichi Okuda,Lisa C. Morton,Ling Sun,Gang Chen,Jason A. Wykoff,Camille Ehre,Juan Vilar,Catharina van Heusden,Alessandra Livraghi-Butrico,Martina Gentzsch,Brian Button,M. J. Stutts,Scott H. Randell,Wanda K. O'Neal,Richard C. Boucher +21 more
TL;DR: Mikami et al. as mentioned in this paper found that chronic hypoxia in airway epithelia led to increased hyperconcentrated mucus production that was at least partially HIF1/HIF2 dependent.