L
Linlin Yin
Researcher at Vanderbilt University
Publications - 6
Citations - 509
Linlin Yin is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Gene targeting & Zebrafish. The author has an hindex of 4, co-authored 4 publications receiving 399 citations.
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Journal ArticleDOI
Active medulloblastoma enhancers reveal subgroup-specific cellular origins
Charles Y. Lin,Charles Y. Lin,Serap Erkek,Yiai Tong,Linlin Yin,Alexander J. Federation,Marc Zapatka,Parthiv Haldipur,Daisuke Kawauchi,Thomas Risch,Hans-Jörg Warnatz,Barbara C. Worst,Bensheng Ju,Brent A. Orr,Rhamy Zeid,Donald R. Polaski,Maia Segura-Wang,Sebastian M. Waszak,David T.W. Jones,Marcel Kool,Volker Hovestadt,Ivo Buchhalter,Laura Sieber,Pascal Johann,Lukas Chavez,Stefan Gröschel,Marina Ryzhova,Andrey Korshunov,Andrey Korshunov,Wenbiao Chen,Victor V. Chizhikov,Kathleen J. Millen,Kathleen J. Millen,Vyacheslav Amstislavskiy,Hans Lehrach,Marie-Laure Yaspo,Roland Eils,Roland Eils,Peter Lichter,Jan O. Korbel,Stefan M. Pfister,Stefan M. Pfister,James E. Bradner,Paul A. Northcott +43 more
TL;DR: In this article, using H3K27ac and BRD4 chromatin immunoprecipitation followed by sequencing (ChIP-seq) coupled with tissue-matched DNA methylation and transcriptome data, the authors describe the active cis-regulatory landscape across 28 primary medulloblastoma specimens.
Journal ArticleDOI
Multiplex Conditional Mutagenesis Using Transgenic Expression of Cas9 and sgRNAs
Linlin Yin,Lisette A. Maddison,Mingyu Li,Nergis Kara,Matthew C. LaFave,Gaurav K. Varshney,Shawn M. Burgess,James G. Patton,Wenbiao Chen +8 more
TL;DR: A system for one-generation multiplex conditional mutagenesis in zebrafish using transgenic expression of both cas9 and multiple single guide RNAs and sgRNAs is demonstrated.
Book ChapterDOI
Generation of Targeted Mutations in Zebrafish Using the CRISPR/Cas System.
TL;DR: A flexible strategy of gene inactivation that allows biallelic inactivation of multiple genes simultaneously by co-injecting a mix of sgRNAs with a single Cas9 construct provides an efficient way to interrogate gene functions and genetic interactions in zebrafish.
Journal ArticleDOI
RIPK3-mediated inflammation is a conserved β cell response to ER stress.
Bingyuan Yang,Lisette A. Maddison,Karolina E. Zaborska,Chunhua Dai,Linlin Yin,Zihan Tang,Liqing Zang,Liqing Zang,David A. Jacobson,Alvin C. Powers,Alvin C. Powers,Wenbiao Chen +11 more
TL;DR: RIPK3-mediated induction of proinflammatory mediators is a conserved, previously unrecognized β cell response to metabolic stress and a mediator of the ensuing islet inflammation.
Journal ArticleDOI
CXCL1/CXCR2 is involved in white matter injury in neonatal rats via the gut–brain axis
TL;DR: In this article , the authors investigated whether CXCL1/CXCR2 mediates intestinal injury or white matter injury by delivering inflammatory mediators through the gut-brain regulation axis.