Alexander J. Federation

TL;DR: A chemical genetic approach reveals a requirement for BET bromodomains in communicating enhancer remodeling to RNA Polymerase II and orchestrating the transition to the inflammatory cell state, demonstrated in activated endothelium and macrophages.

TL;DR: It is proposed that the RNA exosome protects divergently transcribed lncRNA expressing enhancers by resolving deleterious transcription-coupled secondary DNA structures, while also regulating long-range super-enhancer chromosomal interactions important for cellular function.

TL;DR: In this article, using H3K27ac and BRD4 chromatin immunoprecipitation followed by sequencing (ChIP-seq) coupled with tissue-matched DNA methylation and transcriptome data, the authors describe the active cis-regulatory landscape across 28 primary medulloblastoma specimens.

TL;DR: The three-dimensional structure of the protein methyl transferase DOT1L bound to EPZ004777, the first S-adenosylmethionine-competitive inhibitor of a protein methyltransferase with in vivo efficacy, and those of four new analogues reveal remodelling of the catalytic site.

TL;DR: It is reported that most robust AID off-target translocations occur within highly focal regions of target genes in which sense and antisense transcription converge, and it is found that such AID-targeting "convergent" transcription arises fromantisense transcription that emanates from super-enhancers within sense transcribed gene bodies.