S
Solongo B. Ziraldo
Publications - 16
Citations - 5302
Solongo B. Ziraldo is an academic researcher. The author has contributed to research in topics: Transcriptome & Progenitor cell. The author has an hindex of 8, co-authored 15 publications receiving 3436 citations.
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Journal ArticleDOI
Massively parallel digital transcriptional profiling of single cells
Grace X.Y. Zheng,Jessica M. Terry,Phillip Belgrader,Paul Ryvkin,Zachary Bent,Ryan Wilson,Solongo B. Ziraldo,Tobias Daniel Wheeler,Geoffrey P. McDermott,Junjie Zhu,Mark T. Gregory,Joe Shuga,Luz Montesclaros,Jason G. Underwood,Donald A. Masquelier,Stefanie Y. Nishimura,Michael Schnall-Levin,Paul Wyatt,Christopher Hindson,Rajiv Bharadwaj,Alexander Wong,Kevin D. Ness,Lan Beppu,H. Joachim Deeg,Christopher McFarland,Keith R. Loeb,Keith R. Loeb,William J. Valente,William J. Valente,Nolan G. Ericson,Emily A. Stevens,Jerald P. Radich,Tarjei S. Mikkelsen,Benjamin J. Hindson,Jason H. Bielas +34 more
TL;DR: A droplet-based system that enables 3′ mRNA counting of tens of thousands of single cells per sample is described and sequence variation in the transcriptome data is used to determine host and donor chimerism at single-cell resolution from bone marrow mononuclear cells isolated from transplant patients.
Journal ArticleDOI
Non-equivalence of Wnt and R-spondin ligands during Lgr5 + intestinal stem-cell self-renewal
Kelley S. Yan,Kelley S. Yan,Claudia Y. Janda,Junlei Chang,Grace X.Y. Zheng,Kathryn A. Larkin,Vincent C. Luca,Luis A. Chia,Amanda T. Mah,Arnold Han,Arnold Han,Jessica M. Terry,Akifumi Ootani,Kelly Roelf,Mark Lee,Jenny Yuan,Xiao Li,Christopher R. Bolen,Julie Wilhelmy,Paige S. Davies,Hiroo Ueno,Richard J. von Furstenberg,Phillip Belgrader,Solongo B. Ziraldo,Heather Ordonez,Susan J. Henning,Melissa H. Wong,Michael Snyder,Irving L. Weissman,Aaron J. W. Hsueh,Tarjei S. Mikkelsen,K. Christopher Garcia,Calvin J. Kuo +32 more
TL;DR: This functionally non-equivalent yet cooperative interaction between Wnt and RSPO ligands establishes a molecular precedent for regulation of mammalian stem cells by distinct priming and self-renewal factors, with broad implications for precise control of tissue regeneration.
Journal ArticleDOI
Intestinal enteroendocrine lineage cells possess homeostatic and injury-inducible stem cell activity
Kelley S. Yan,Kelley S. Yan,Olivier Gevaert,Grace X.Y. Zheng,Benedict Anchang,Chris Probert,Kathryn A. Larkin,Paige S. Davies,Zhuan fen Cheng,John S. Kaddis,Arnold Han,Arnold Han,Kelly Roelf,Ruben I. Calderon,Esther Cynn,Xiaoyi Hu,Komal Mandleywala,Julie Wilhelmy,Susan M. Grimes,David C Corney,Stéphane C. Boutet,Jessica M. Terry,Phillip Belgrader,Solongo B. Ziraldo,Tarjei S. Mikkelsen,Fengchao Wang,Richard J. von Furstenberg,Nicholas R. Smith,Parthasarathy Chandrakesan,Randal May,Mary Ann S. Chrissy,Rajan Jain,Christine A. Cartwright,Joyce C. Niland,Young-Kwon Hong,Jill L. Carrington,David T. Breault,Jonathan I. Epstein,Courtney W. Houchen,John P. Lynch,Martin G. Martin,Sylvia K. Plevritis,Christina Curtis,Hanlee P. Ji,Linheng Li,Susan J. Henning,Melissa H. Wong,Calvin J. Kuo +47 more
TL;DR: The data suggest that the EE lineage, including mature EE cells, comprises a reservoir of homeostatic and injury-inducible ISCs, extending the understanding of cellular plasticity and stemness.
Journal ArticleDOI
Progenitor identification and SARS-CoV-2 infection in human distal lung organoids.
Ameen A. Salahudeen,Ameen A. Salahudeen,Shannon S. Choi,Arjun Rustagi,Junjie Zhu,Vincent van Unen,Sean M. de la O,Ryan A. Flynn,Mar Margalef-Català,António J. M. Santos,Jihang Ju,Arpit Batish,Tatsuya Usui,Grace X.Y. Zheng,Caitlin E. Edwards,Lisa E. Wagar,Vincent C. Luca,Benedict Anchang,Monica Nagendran,Khanh Nguyen,Daniel J. Hart,Jessica M. Terry,Phillip Belgrader,Solongo B. Ziraldo,Tarjei S. Mikkelsen,Pehr B. Harbury,Jeffrey S. Glenn,K. Christopher Garcia,Mark M. Davis,Ralph S. Baric,Chiara Sabatti,Manuel R. Amieva,Catherine A. Blish,Tushar J. Desai,Calvin J. Kuo +34 more
TL;DR: A facile in vitro organoid model of human distal lung infections, including COVID-19-associated pneumonia, is established and a long-term culture method for organoids derived from single adult human lung cells is used to identify progenitor cells and study SARS-CoV-2 infection.
Posted ContentDOI
Massively parallel digital transcriptional profiling of single cells
Grace X.Y. Zheng,Jessica M. Terry,Phillip Belgrader,Paul Ryvkin,Zachary Bent,Ryan Wilson,Solongo B. Ziraldo,Tobias Daniel Wheeler,Geoffrey P. McDermott,Junjie Zhu,Mark T. Gregory,Joe Shuga,Luz Montesclaros,Donald A. Masquelier,Stefanie Y. Nishimura,Michael Schnall-Levin,Paul Wyatt,Christopher Hindson,Rajiv Bharadwaj,Alexander Wong,Kevin D. Ness,Lan Beppu,H. Joachim Deeg,Christopher McFarland,Keith R. Loeb,William J. Valente,Nolan G. Ericson,Emily A. Stevens,Jerald P. Radich,Tarjei S. Mikkelsen,Benjamin J. Hindson,Jason H. Bielas +31 more
TL;DR: A droplet-based system that enables 3′ mRNA counting of up to tens of thousands of single cells per sample is described and enables characterization of diverse biological systems with single cell mRNA analysis.