L
Liuliu Yang
Researcher at Chinese Academy of Sciences
Publications - 30
Citations - 1905
Liuliu Yang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Induced pluripotent stem cell & Innate lymphoid cell. The author has an hindex of 14, co-authored 24 publications receiving 1059 citations. Previous affiliations of Liuliu Yang include Cornell University.
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Journal ArticleDOI
A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids.
Liuliu Yang,Yuling Han,Benjamin E. Nilsson-Payant,Vikas Gupta,Pengfei Wang,Xiaohua Duan,Xiaohua Duan,Xuming Tang,Jiajun Zhu,Zeping Zhao,Fabrice Jaffré,Tuo Zhang,Tae Wan Kim,Oliver Harschnitz,David Redmond,Sean Houghton,Chengyang Liu,Ali Naji,Gabriele Ciceri,Sudha R Guttikonda,Yaron Bram,Duc-Huy T. Nguyen,Michele Cioffi,Vasuretha Chandar,Daisy A. Hoagland,Yaoxing Huang,Jenny Xiang,Hui Wang,Hui Wang,David Lyden,Alain C. Borczuk,Huanhuan Joyce Chen,Lorenz Studer,Fong Cheng Pan,David D. Ho,Benjamin R. tenOever,Todd Evans,Robert E. Schwartz,Shuibing Chen +38 more
TL;DR: It is found that human pancreatic beta cells and liver organoids are highly permissive to SARS-CoV-2 infection, further validated using adult primary human islets and adult hepatocyte and cholangiocyte organoids.
Journal ArticleDOI
Identification of SARS-CoV-2 inhibitors using lung and colonic organoids.
Yuling Han,Xiaohua Duan,Xiaohua Duan,Liuliu Yang,Benjamin E. Nilsson-Payant,Pengfei Wang,Fuyu Duan,Xuming Tang,Tomer M. Yaron,Tuo Zhang,Skyler Uhl,Yaron Bram,Chanel Richardson,Jiajun Zhu,Zeping Zhao,David Redmond,Sean Houghton,Duc-Huy T. Nguyen,Dong Xu,Xing Wang,Jose Jessurun,Alain C. Borczuk,Yaoxing Huang,Jared L. Johnson,Yuru Liu,Jenny Xiang,Hui Wang,Lewis C. Cantley,Benjamin R. tenOever,David D. Ho,Fong Cheng Pan,Todd Evans,Huanhuan Joyce Chen,Huanhuan Joyce Chen,Robert E. Schwartz,Shuibing Chen +35 more
TL;DR: This work developed a lung organoid model using human pluripotent stem cells (hPSC-LOs) and performed a high-throughput screen of drugs approved by the FDA and identified entry inhibitors of SARS-CoV-2, including imatinib, mycophenolic acid and quinacrine dihydrochloride.
Journal ArticleDOI
Long noncoding RNA lncKdm2b is required for ILC3 maintenance by initiation of Zfp292 expression
Benyu Liu,Buqing Ye,Liuliu Yang,Xiaoxiao Zhu,Guanling Huang,Pingping Zhu,Ying Du,Jiayi Wu,Xiwen Qin,Runsheng Chen,Yong Tian,Zusen Fan +11 more
TL;DR: It is observed that a divergent long noncoding RNA (lncRNA), lncKdm2b, was expressed at high levels in intestinal group 3 ILCs (ILC3s).
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IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3.
Pingping Zhu,Xiaoxiao Zhu,Jiayi Wu,L.L. He,Tiankun Lu,Yanying Wang,Benyu Liu,Buqing Ye,Lei Sun,Dongdong Fan,Jing Wang,Liuliu Yang,Xiwen Qin,Ying Du,Chong Li,Lei He,Weizheng Ren,Xin Wu,Yong Tian,Zusen Fan +19 more
TL;DR: It is found that mouse and human Lgr5+ ISCs showed high expression of the immune cell–associated circular RNA circPan3 (originating from the Pan3 gene transcript) and, thus, the renewal of those cells in response to IL-13 derived from group 2 innate lymphoid cells.
Journal ArticleDOI
The long non-coding RNA LncHDAC2 drives the self-renewal of liver cancer stem cells via activation of Hedgehog signaling
Jiayi Wu,Pingping Zhu,Tiankun Lu,Ying Du,Yanying Wang,L.L. He,Buqing Ye,Benyu Liu,Liuliu Yang,Jing Wang,Yang Gu,Jie Lan,Yajing Hao,Lei He,Zusen Fan +14 more
TL;DR: The findings reveal that lncHDAC2 promotes the self-renewal of liver CSCs and tumor propagation by activating the Hedgehog signaling pathway.