L
Lorraine F. Lanyon
Researcher at Pfizer
Publications - 18
Citations - 646
Lorraine F. Lanyon is an academic researcher from Pfizer. The author has contributed to research in topics: Protease & Coronavirus. The author has an hindex of 10, co-authored 18 publications receiving 357 citations.
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Journal ArticleDOI
Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19.
Britton Boras,Rhys M. Jones,Brandon J. Anson,Dan Arenson,Lisa Aschenbrenner,Malina A. Bakowski,Nathan Beutler,Joseph John Binder,Emily I. Chen,Heather Eng,Holly L. Hammond,Jennifer Hammond,Robert Haupt,Robert M. Hoffman,Eugene P. Kadar,Rob Kania,Emi Kimoto,Melanie G. Kirkpatrick,Lorraine F. Lanyon,Emma K. Lendy,Lillis Jonathan Richard,James Logue,Suman Luthra,Chunlong Ma,Stephen W. Mason,Marisa McGrath,Stephen Noell,R. Scott Obach,Matthew N O' Brien,Rebecca E. O’Connor,Kevin Ogilvie,Dafydd R. Owen,Martin Pettersson,Matthew R. Reese,Thomas F. Rogers,Thomas F. Rogers,Romel Rosales,Michelle Rossulek,Jean G. Sathish,Norimitsu Shirai,Claire M. Steppan,Martyn D. Ticehurst,Lawrence W. Updyke,Stuart Weston,Yuao Zhu,Kris M. White,Adolfo García-Sastre,Jun Wang,Arnab K. Chatterjee,Andrew D. Mesecar,Matthew B. Frieman,Annaliesa S. Anderson,Charlotte Moira Norfor Allerton +52 more
TL;DR: In this paper, a phosphate prodrug PF-07304814 was developed to inhibit coronavirus family 3CL protease activity with selectivity over human host protease targets.
Posted ContentDOI
Discovery of a Novel Inhibitor of Coronavirus 3CL Protease as a Clinical Candidate for the Potential Treatment of COVID-19
Britton Boras,Rhys M. Jones,Brandon J. Anson,Dan Arenson,Lisa Aschenbrenner,Malina A. Bakowski,Nathan Beutler,Joseph John Binder,Emily I. Chen,Heather Eng,Jennifer Hammond,Robert M. Hoffman,Eugene P. Kadar,Robert Steven Kania,Emi Kimoto,Melanie G. Kirkpatrick,Lorraine F. Lanyon,Emma K. Lendy,Lillis Jonathan Richard,Suman Luthra,Chunlong Ma,Stephen Noell,R. Scott Obach,Kevin Ogilvie,Dafydd R. Owen,Martin Pettersson,Mattew R. Reese,Thomas F. Rogers,Thomas F. Rogers,Michelle Rossulek,Jean G. Sathish,Claire M. Steppan,Martyn D. Ticehurst,Lawrence W. Updyke,Yuao Zhu,Jun Wang,Arnab K. Chatterjee,Andrew D. Mesecar,Annaliesa S. Anderson,Charlotte Moira Norfor Allerton,Matthew B. Frieman,Stuart Weston,Marisa McGrath,James Logue,Robert Haupt,Holly L. Hammond,Stephen W. Mason,Norimitsu Shirai +47 more
TL;DR: The ADME, safety, in vitro, and in vivo antiviral activity data that supports the clinical evaluation of this compound as a potential COVID-19 treatment are presented.
Posted ContentDOI
Discovery of a Novel Inhibitor of Coronavirus 3CL Protease for the Potential Treatment of COVID-19
Britton Boras,Rhys M. Jones,Brandon J. Anson,Dan Arenson,Lisa Aschenbrenner,Malina A. Bakowski,Nathan Beutler,Joseph John Binder,Emily I. Chen,Heather Eng,Holly L. Hammond,Jennifer Hammond,Rob Haupt,Robert M. Hoffman,Eugene P. Kadar,Robert Steven Kania,Emi Kimoto,Melanie G. Kirkpatrick,Lorraine F. Lanyon,Emma K. Lendy,Lillis,James Logue,Suman Luthra,Chuang Ma,Stephen W. Mason,Marisa McGrath,Stephen Noell,Obach Rs,O’Brien Mn,Rebecca E. O’Connor,Kevin Ogilvie,Dafydd R. Owen,Martin Pettersson,Reese Mr,Thomas F. Rogers,Thomas F. Rogers,Michelle Rossulek,Jean G. Sathish,Norimitsu Shirai,Claire M. Steppan,Martyn D. Ticehurst,Lawrence W. Updyke,Stuart Weston,Yuao Zhu,Jun Wang,Abhishek Chatterjee,Andrew D. Mesecar,Matthew B. Frieman,Annaliesa S. Anderson,Charlotte Moira Norfor Allerton +49 more
TL;DR: In this paper, a phosphate prodrug PF-07304814 is metabolized to PF-00835321 which is a potent inhibitor in vitro of the coronavirus family 3CL pro, with selectivity over human host protease targets.
Journal ArticleDOI
Spirocyclic sulfamides as β-secretase 1 (BACE-1) inhibitors for the treatment of Alzheimer's disease: utilization of structure based drug design, WaterMap, and CNS penetration studies to identify centrally efficacious inhibitors.
Michael Aaron Brodney,Gabriela Barreiro,Kevin Ogilvie,Eva Hajos-Korcsok,John C. Murray,Felix Vajdos,Claude Ambroise,Curt Christoffersen,Katherine Fisher,Lorraine F. Lanyon,Jianhua Liu,Charles E. Nolan,Jane M. Withka,Kris A. Borzilleri,Ivan Viktorovich Efremov,Christine E. Oborski,Alison H. Varghese,Brian T. O’Neill +17 more
TL;DR: Compound 14g is a potent inhibitor of BACE-1 with excellent permeability and a moderate P-gp liability, and Administration of 14g to mice produced a significant, dose-dependent reduction in central Aβ(X-40) levels at a free drug exposure equivalent to the whole cell IC(50) (100 nM).
Journal ArticleDOI
Discovery of a Highly Selective Glycogen Synthase Kinase‐3 Inhibitor (PF‐04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging
Steven H. Liang,Jinshan Michael Chen,Marc D. Normandin,Jeanne S. Chang,George Chang,Christine K. Taylor,Patrick Trapa,Mark S. Plummer,Kimberly Suzanne Para,Edward L. Conn,Lori L. Lopresti-Morrow,Lorraine F. Lanyon,James M. Cook,Karl E.G. Richter,Charlie E. Nolan,Joel B. Schachter,Fouad Janat,Ye Che,Veerabahu Shanmugasundaram,Bruce Allen Lefker,Bradley E. Enerson,E. Livni,Lu Wang,Nicolas Guehl,Debasis Patnaik,Florence F. Wagner,Roy H. Perlis,Roy H. Perlis,Edward B. Holson,Stephen J. Haggarty,Georges El Fakhri,Ravi G. Kurumbail,Neil Vasdev +32 more
TL;DR: Preliminary PET imaging studies in non-human primates confirmed that the two major obstacles for imaging GSK-3, namely, reasonable brain permeability and displaceable binding, are overcome.