L
Lothar Hennighausen
Researcher at National Institutes of Health
Publications - 337
Citations - 32940
Lothar Hennighausen is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Transcription factor & Gene. The author has an hindex of 96, co-authored 316 publications receiving 31267 citations. Previous affiliations of Lothar Hennighausen include Chonnam National University & Dankook University.
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Journal ArticleDOI
Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation
Arian Laurence,Cristina M. Tato,Todd S. Davidson,Yuka Kanno,Zhi Chen,Zhengju Yao,Rebecca Blank,Françoise Meylan,Richard M. Siegel,Lothar Hennighausen,Ethan M. Shevach,John J. O'Shea +11 more
TL;DR: It is demonstrated that in addition to the promotion of activation-induced cell death of lymphocytes and the generation of Treg cells, inhibition of Th17 polarization appears to be an important function of IL-2.
Journal ArticleDOI
Stat5a is mandatory for adult mammary gland development and lactogenesis.
Xiuwen Liu,Gertraud W. Robinson,Kay Uwe Wagner,Lisa Garrett,Anthony Wynshaw-Boris,Lothar Hennighausen +5 more
TL;DR: It is document that Stat5a is the principal and an obligate mediator of mammopoietic and lactogenic signaling.
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Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system.
Jason S. Stumhofer,Arian Laurence,Emma H. Wilson,Elaine Huang,Cristina M. Tato,Leanne M. Johnson,Alejandro V. Villarino,Qiulong Huang,Akihiko Yoshimura,David Sehy,Christiaan J. M. Saris,John J. O'Shea,Lothar Hennighausen,Matthias Ernst,Christopher A. Hunter +14 more
TL;DR: It is shown that IL-27 receptor–deficient mice chronically infected with Toxoplasma gondii developed severe neuroinflammation that was CD4+ T cell dependent and was associated with a prominent IL-17 response.
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Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter
Priscilla A. Furth,L St Onge,H Böger,Peter Gruss,Manfred Gossen,A Kistner,Hermann Bujard,Lothar Hennighausen +7 more
TL;DR: A tetracycline-responsive binary system for its ability to temporally control gene expression in transgenic mice is evaluated and can be used to design dominant gain-of-function experiments in which temporal control of transgene expression is required.
Journal ArticleDOI
Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.
Xiaoling Xu,Kay Uwe Wagner,Denise M. Larson,Zoë Weaver,Cuiling Li,Thomas Ried,Lothar Hennighausen,Anthony Wynshaw-Boris,Chu-Xia Deng +8 more
TL;DR: It is demonstrated that disruption of Brca1 causes genetic instability and triggers further alterations, including the inactivation of p53, that lead to tumour formation.