L
Louis Picard
Researcher at Université de Montréal
Publications - 6
Citations - 150
Louis Picard is an academic researcher from Université de Montréal. The author has contributed to research in topics: Medicine & G protein-coupled receptor. The author has an hindex of 2, co-authored 3 publications receiving 102 citations.
Papers
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Journal ArticleDOI
Structural insights into binding specificity, efficacy and bias of a beta2AR partial agonist.
Matthieu Masureel,Yaozhong Zou,Louis Picard,Emma T van der Westhuizen,Emma T van der Westhuizen,Jacob P. Mahoney,João P. G. L. M. Rodrigues,Thomas J. Mildorf,Ron O. Dror,David E. Shaw,Michel Bouvier,Els Pardon,Jan Steyaert,Roger K. Sunahara,William I. Weis,Cheng Zhang,Brian K. Kobilka +16 more
TL;DR: The active-state structure of a GPCR occupied by a partial agonist, β2AR with salmeterol, together with mutagenesis and biophysical studies, explains this ligand's unusual pharmacological profile.
Journal ArticleDOI
Publisher Correction: Structural insights into binding specificity, efficacy and bias of a β 2 AR partial agonist
Matthieu Masureel,Yaozhong Zou,Louis Picard,Emma T van der Westhuizen,Emma T van der Westhuizen,Jacob P. Mahoney,Jacob P. Mahoney,João P. G. L. M. Rodrigues,Thomas J. Mildorf,Ron O. Dror,Ron O. Dror,David E. Shaw,David E. Shaw,Michel Bouvier,Els Pardon,Jan Steyaert,Roger K. Sunahara,William I. Weis,Cheng Zhang,Brian K. Kobilka +19 more
TL;DR: In the version of this paper originally published, the structure for epinephrine shown in Figure 1a was redrawn with an extra carbon and has been replaced in the HTML and PDF versions of the article.
Journal ArticleDOI
Mapping the conformational landscape of the stimulatory heterotrimeric G protein
Shuya K. Huang,Louis Picard,Aditya Pandey,Ned Van Eps,Roger K. Sunahara,Oliver P. Ernst,Adnan Sljoka,R. Scott Prosser +7 more
Journal ArticleDOI
Measuring the rupture force between adenosine A2A G-protein coupled receptors and G-proteins using axial optical tweezers.
TL;DR: In this article , axial optical tweezers are used to measure the rupture force between the adenosine A2A receptor in a nanodisc and its associated G-protein.