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Ned Van Eps
Researcher at University of Toronto
Publications - 36
Citations - 3035
Ned Van Eps is an academic researcher from University of Toronto. The author has contributed to research in topics: Rhodopsin & G protein-coupled receptor. The author has an hindex of 23, co-authored 34 publications receiving 2553 citations. Previous affiliations of Ned Van Eps include Jules Stein Eye Institute & University of California, Santa Cruz.
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Journal ArticleDOI
Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser
Yanyong Kang,X. Edward Zhou,Xiang Gao,Yuanzheng He,Wei Liu,Andrii Ishchenko,Anton Barty,Thomas A. White,Oleksandr Yefanov,Gye Won Han,Qingping Xu,Parker W. de Waal,Jiyuan Ke,M. H. Eileen Tan,Chenghai Zhang,Arne Moeller,Graham M. West,Bruce D. Pascal,Ned Van Eps,Lydia N. Caro,Sergey A. Vishnivetskiy,Regina J. Lee,Kelly Suino-Powell,Xin Gu,Kuntal Pal,Jinming Ma,Xiaoyong Zhi,Sébastien Boutet,Garth J. Williams,Marc Messerschmidt,Cornelius Gati,Nadia A. Zatsepin,Dingjie Wang,Daniel James,Shibom Basu,Shatabdi Roy-Chowdhury,Chelsie E. Conrad,Jesse Coe,Haiguang Liu,Stella Lisova,Christopher Kupitz,Ingo Grotjohann,Raimund Fromme,Yi Jiang,Minjia Tan,Huaiyu Yang,Jun Li,Meitian Wang,Zhong Zheng,Dianfan Li,Nicole Howe,Yingming Zhao,Jörg Standfuss,Kay Diederichs,Yuhui Dong,Clinton S. Potter,Bridget Carragher,Martin Caffrey,Hualiang Jiang,Henry N. Chapman,John C. H. Spence,Petra Fromme,Uwe Weierstall,Oliver P. Ernst,Vsevolod Katritch,Vsevolod V. Gurevich,Patrick R. Griffin,Wayne L. Hubbell,Raymond C. Stevens,Vadim Cherezov,Karsten Melcher,H. Eric Xu +71 more
TL;DR: The crystal structure of a constitutively active form of human rhodopsin bound to a pre-activated form of the mouse visual arrestin is determined by serial femtosecond X-ray laser crystallography and provides a basis for understanding GPCR-mediated arrestin-biased signalling.
Journal ArticleDOI
Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors
X. Edward Zhou,X. Edward Zhou,Yuanzheng He,Parker W. de Waal,Xiang Gao,Yanyong Kang,Ned Van Eps,Yanting Yin,Yanting Yin,Kuntal Pal,Devrishi Goswami,Thomas A. White,Anton Barty,Naomi R. Latorraca,Henry N. Chapman,Wayne L. Hubbell,Ron O. Dror,Raymond C. Stevens,Raymond C. Stevens,Vadim Cherezov,Vsevolod V. Gurevich,Patrick R. Griffin,Oliver P. Ernst,Karsten Melcher,H. Eric Xu,H. Eric Xu +25 more
TL;DR: An X-ray free electron laser (XFEL) crystal structure of the rhodopsin-arrestin complex is reported, in which the phosphorylated C terminus of r Rhodopsin forms an extended intermolecular β sheet with the N-terminal β strands of arrestin.
Journal ArticleDOI
Activation of the A2A adenosine G-protein-coupled receptor by conformational selection
TL;DR: Direct observation of the conformational equilibria of ligand-dependent G-protein-coupled receptor and deduction of the underlying mechanisms of receptor activation will have wide-reaching implications for the understanding of the function of G- proteins in health and disease.
Journal ArticleDOI
Cryo-EM structure of human rhodopsin bound to an inhibitory G protein
Yanyong Kang,Oleg Kuybeda,Parker W. de Waal,Somnath Mukherjee,Ned Van Eps,Przemysław Dutka,Przemysław Dutka,X. Edward Zhou,Alberto Bartesaghi,Satchal K. Erramilli,Takefumi Morizumi,Xin Gu,Yanting Yin,Ping Liu,Yi Jiang,Xing Meng,Gongpu Zhao,Karsten Melcher,Oliver P. Ernst,Anthony A. Kossiakoff,Sriram Subramaniam,H. Eric Xu,H. Eric Xu +22 more
TL;DR: It is shown that the major interactions between activated rhodopsin and Gi are mediated by the C-terminal helix of the Gi α-subunit, which is wedged into the cytoplasmic cavity of the transmembrane helix bundle and directly contacts the amino terminus of helix 8 of rhodopin.
Journal ArticleDOI
Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins.
TL;DR: These data provide the first direct observation of R*-mediated conformational changes in G proteins and define the structural basis for GDP release from G α using electron paramagnetic resonance spectroscopy.