Louise Male

TL;DR: In this article, the solid state structures of free seven-membered N-heterocyclic carbenes have been determined (7-Mes and 7-Xyl).

TL;DR: A chiral ferrocene-based boronic acid interacts with (R)- and (S)-Binol to form two complexes that exhibit significantly different ferrocenes-based electrode potentials, which can be exploited to demonstrate in principle how high levels of enantiomeric excess in a mixture ofEnantiomers can be quantified and read-out using an electrochemical method.

TL;DR: The results showed that these compounds mediate a strong cytotoxic response to normal and cancer cell lines tested through apoptosis and induce cell cycle arrest in S phase of the cell cycle, suggesting DNA intercalation (direct or indirect) with the complexes.

TL;DR: Both isomers of ferrocene carboxaldehyde displayed in vitro toxicity against B16 melanoma and Vero cell lines in the micromolar range and inhibited the kinase VEGFR-2 with IC(50) values of ca.

TL;DR: N-alkylation of a novel pyridine sensor results in pyridinium salts whose conformations are stabilised by pyrIDinium cation-π interactions resulting in a fluorescent response that can be used to sense the presence of alkylating agents in solution at low concentration.