E
Elizabeth S. Maywood
Researcher at University of Cambridge
Publications - 30
Citations - 6786
Elizabeth S. Maywood is an academic researcher from University of Cambridge. The author has contributed to research in topics: Circadian rhythm & Circadian clock. The author has an hindex of 23, co-authored 30 publications receiving 6429 citations. Previous affiliations of Elizabeth S. Maywood include New York University & Laboratory of Molecular Biology.
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Journal ArticleDOI
mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop.
Kazuhiko Kume,Mark J. Zylka,Sathyanarayanan Sriram,Lauren P. Shearman,David R. Weaver,Xiaowei Jin,Elizabeth S. Maywood,Michael H. Hastings,Steven M. Reppert +8 more
TL;DR: It is determined that two mouse cryptochrome genes, mCry1 and mCry2, act in the negative limb of the clock feedback loop, and the mPER and mCRY proteins appear to inhibit the transcriptional complex differentially.
Journal ArticleDOI
Interacting Molecular Loops in the Mammalian Circadian Clock
Lauren P. Shearman,Sathyanarayanan Sriram,David R. Weaver,Elizabeth S. Maywood,Inẽs Chaves,Binhai Zheng,Kazuhiko Kume,Cheng Chi Lee,Gijsbertus T. J. van der,Horst,Michael H. Hastings,Steven M. Reppert +11 more
TL;DR: Analysis of Clock/Clock mutant mice, homozygous Period2(Brdm1) mutants, and Cryptochrome-deficient mice reveals substantially altered Bmal1 rhythms, consistent with a dominant role of PERIOD2 in the positive regulation of the Bmal 1 loop.
Journal ArticleDOI
Differential Functions of mPer1, mPer2, and mPer3 in the SCN Circadian Clock
Kiho Bae,Xiaowei Jin,Elizabeth S. Maywood,Michael H. Hastings,Michael H. Hastings,Steven M. Reppert,David R. Weaver +6 more
TL;DR: It is confirmed that mPER1 influences rhythmicity primarily through interaction with other clock proteins, while mPER2 positively regulates rhythmic gene expression, and there is partial compensation between products of these two genes.
Journal ArticleDOI
The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period.
Sofia I. H. Godinho,Sofia I. H. Godinho,Sofia I. H. Godinho,Elizabeth S. Maywood,Elizabeth S. Maywood,Elizabeth S. Maywood,Linda Shaw,Linda Shaw,Linda Shaw,Valter Tucci,Valter Tucci,Valter Tucci,Alun R. Barnard,Alun R. Barnard,Alun R. Barnard,Luca Busino,Luca Busino,Luca Busino,Michele Pagano,Michele Pagano,Michele Pagano,Rachel Kendall,Rachel Kendall,Rachel Kendall,Mohamed M. Quwailid,Mohamed M. Quwailid,Mohamed M. Quwailid,M. Rosario Romero,M. Rosario Romero,M. Rosario Romero,John S. O’Neill,John S. O’Neill,John S. O’Neill,Johanna E. Chesham,Johanna E. Chesham,Johanna E. Chesham,Debra Brooker,Debra Brooker,Debra Brooker,Zuzanna Lalanne,Zuzanna Lalanne,Zuzanna Lalanne,Michael H. Hastings,Michael H. Hastings,Michael H. Hastings,Patrick M. Nolan,Patrick M. Nolan,Patrick M. Nolan +47 more
TL;DR: In vivo and in vitro studies reveal a central role for Fbxl3 in mammalian circadian timekeeping and identify a mouse mutation, after hours (Afh), which results in long free-running rhythms of about 27 hours in homozygotes.
Journal ArticleDOI
cAMP-dependent signaling as a core component of the mammalian circadian pacemaker.
John S. O’Neill,Elizabeth S. Maywood,Johanna E. Chesham,Joseph S. Takahashi,Michael H. Hastings +4 more
TL;DR: It is proposed that daily activation of cAMP signaling, driven by the transcriptional oscillator, in turn sustains progression of transcriptional rhythms, and clock output constitutes an input to subsequent cycles.