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Open AccessJournal ArticleDOI

Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet

Megumi Hatori, +12 more
- 06 Jun 2012 - 
- Vol. 15, Iss: 6, pp 848-860
TLDR
Mice under tRF consume equivalent calories from HFD as those with ad lib access yet are protected against obesity, hyperinsulinemia, hepatic steatosis, and inflammation and have improved motor coordination.
About: 
This article is published in Cell Metabolism.The article was published on 2012-06-06 and is currently open access. It has received 1442 citations till now. The article focuses on the topics: Hyperinsulinemia.

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Citations
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Journal ArticleDOI

The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43

Ikuo Kimura, +14 more
- 07 May 2013 - 
TL;DR: It is demonstrated that G PR43-deficient mice are obese on a normal diet, whereas mice overexpressing GPR43 specifically in adipose tissue remain lean even when fed a high-fat diet.
Journal ArticleDOI

Promoting Health and Longevity through Diet: From Model Organisms to Humans

Luigi Fontana, +1 more
- 26 Mar 2015 - 
TL;DR: Findings indicate that meal timing is crucial, with both intermittent fasting and adjusted diurnal rhythm of feeding improving health and function, in the absence of changes in overall intake.
Journal ArticleDOI

Diet dominates host genotype in shaping the murine gut microbiota.

Rachel N. Carmody, +7 more
- 14 Jan 2015 - 
TL;DR: Repeated dietary shifts demonstrated that most changes to the gut microbiota are reversible, while also uncovering bacteria whose abundance depends on prior consumption, emphasizing the dominant role that diet plays in shaping interindividual variations in host-associated microbial communities.
Journal ArticleDOI

Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes.

Elizabeth F. Sutton, +7 more
- 05 Jun 2018 - 
TL;DR: It is demonstrated for the first time in humans that eTRF improves some aspects of cardiometabolic health and that IF's effects are not solely due to weight loss.
Journal ArticleDOI

Effects of Intermittent Fasting on Health, Aging, and Disease

Rafael de Cabo, +1 more
- 25 Dec 2019 - 
TL;DR: Effects of Intermittent Fasting on Health and Aging evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-base fasting.
References
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Journal ArticleDOI

National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9·1 million participants

Mariel M. Finucane, +12 more
- 12 Feb 2011 - 
TL;DR: In this paper, the authors estimated trends and their uncertainties of mean BMI for adults 20 years and older in 199 countries and territories, and used a Bayesian hierarchical model to estimate mean BMI by age, country, and year.
Journal ArticleDOI

Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice

Fred W. Turek, +19 more
- 13 May 2005 - 
TL;DR: Estimation of transcripts encoding selected hypothalamic peptides associated with energy balance was attenuated in the Clock mutant mice, suggesting that the circadian clock gene network plays an important role in mammalian energy balance.
Journal ArticleDOI

The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator.

Nicolas Preitner, +6 more
- 26 Jul 2002 - 
TL;DR: The orphan nuclear receptor REV-ERBalpha is identified as the major regulator of cyclic Bmal1 transcription, and constitutes a molecular link through which components of the negative limb drive antiphasic expression of component of the positive limb.
Journal ArticleDOI

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

Mitsuhiro Watanabe, +12 more
- 26 Jan 2006 - 
TL;DR: It is shown that the administration of BAs to mice increases energy expenditure in brown adipose tissue, preventing obesity and resistance to insulin, and indicates that BAs might be able to function beyond the control of BA homeostasis as general metabolic integrators.
Journal ArticleDOI

The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

Reuben J. Shaw, +9 more
- 09 Dec 2005 - 
TL;DR: It is shown that metformin, one of the most widely prescribed type 2 diabetes therapeutics, requires LKB1 in the liver to lower blood glucose levels, and TORC2 is a critical target of L KB1/AMPK signals in the regulation of gluconeogenesis.
Related Papers (5)

High-fat diet disrupts behavioral and molecular circadian rhythms in mice.

Akira Kohsaka, +8 more
- 07 Nov 2007 - 

Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice

Fred W. Turek, +19 more
- 13 May 2005 - 

Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus

Francesca Damiola, +5 more
- 01 Dec 2000 - 

Adverse metabolic and cardiovascular consequences of circadian misalignment

Frank A.J.L. Scheer, +4 more
- 17 Mar 2009 - 

Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

Biliana Marcheva, +17 more
- 29 Jul 2010 -